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Literature summary for 4.1.2.47 extracted from

  • Koch, K.; van den Berg, R.J.; Nieuwland, P.J.; Wijtmans, R.; Wubbolts, M.G.; Schoemaker, H.E.; Rutjes, F.P.; van Hest, J.C.
    Enzymatic synthesis of optically pure cyanohydrins in microchannels using a crude cell lysate (2008), Chem. Eng. J., 135, S89-S92.
No PubMed abstract available
Search for more literature for 4.1.2.47

Application

Application Comment Organism
synthesis crude cell lysate containing a hydroxynitrile lyase can be used for the enantioselective synthesis of several cyanohydrins in a microchannel. These enzymatic reactions show a high initial reaction rate and enantioselectivity, which in a batchwise process can only be achieved by vigorous stirring Hevea brasiliensis

Cloned(Commentary)

Cloned (Comment) Organism
expressed in the yeast strain Pichia pastoris Hevea brasiliensis

Organism

Organism UniProt Comment Textmining
Hevea brasiliensis
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cell lysate
-
 Hevea brasiliensis
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cyanide + 3-phenylpropanal
-
 Hevea brasiliensis (2S)-2-hydroxy-4-phenylbutanenitrile
-
 ?
cyanide + 4-methoxybenzaldehyde
-
 Hevea brasiliensis (2S)-4-methoxymandelonitrile
-
 ?
cyanide + benzaldehyde
-
 Hevea brasiliensis (S)-mandelonitrile
-
 ?
cyanide + thiophene-2-carbaldehyde
-
 Hevea brasiliensis (2S)-hydroxy(thiophen-2-yl)ethanenitrile
-
 ?

Synonyms

Synonyms Comment Organism
(S)-HbHNL
-
 Hevea brasiliensis
(S)-selective hydroxynitrile lyase
-
 Hevea brasiliensis
Hydroxynitrile lyase
-
 Hevea brasiliensis