Literature summary for 4.1.2.47 extracted from

Purkarthofer, T.; Skranc, W.; Schuster, C.; Griengl, H.
Potential and capabilities of hydroxynitrile lyases as biocatalysts in the chemical industry (2007), Appl. Microbiol. Biotechnol., 76, 309-320.

Search for more literature for 4.1.2.47

Application

Application	Comment	Organism
drug development	industrial processes	Hevea brasiliensis

Cloned(Commentary)

Cloned (Comment)	Organism
cloned and produced by heterologous expression in different microbial hosts	Hevea brasiliensis

Crystallization (Commentary)

Crystallization (Comment)	Organism
three-dimensional structure analysis, catalytic triad consisting of serine, histidine and aspartic acid	Hevea brasiliensis

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
2-hydroxy-2-methylpropanenitrile	Hevea brasiliensis	-	acetone + HCN	-	r

Organism

Organism	UniProt	Comment	Textmining
Hevea brasiliensis	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
(1S)-1-furan-2-yl-2-nitroethanol	enantiomeric excess: ~90%, yield: 60-70%	Hevea brasiliensis	furan-2-carbaldehyde + CH3NO2	-	r
(1S)-2-nitro-1-(4-nitrophenyl)ethanol	enantiomeric excess: ~90%, yield: 60-70%	Hevea brasiliensis	4-nitrobenzaldehyde + CH3NO2	-	r
(1S)-2-nitro-1-phenylethanol	enantiomeric excess: ~90%, yield: 60-70%	Hevea brasiliensis	benzaldehyde + CH3NO2	-	r
(1S,2R)-2-nitro-1-phenyl-propanol	4 diastereomers, enantiomeric excess: 95%, yield: 67%	Hevea brasiliensis	benzaldehyde + C2H5NO2	-	r
(2S)-1-nitrooctan-2-ol	enantiomeric excess: ~90%, yield: 60-70%	Hevea brasiliensis	heptanal + CH3NO2	-	r
(R)-2-(2-furyl)-2-hydroxyacetonitrile	enantiomeric excess: > 99%, yield: 90%	Hevea brasiliensis	furan-2-carbaldehyde + HCN	-	r
(S)-3-phenoxybenzaldehyde cyanohydrin	enantiomeric excess: > 98.5%, yield: 95.5%, used for insecticide synthesis	Hevea brasiliensis	m-phenoxybenzaldyhyde + HCN	-	r
(S)-mandelonitrile	enantiomeric excess: > 99%, yield: 90%	Hevea brasiliensis	benzaldehyde + HCN	-	r
2-hydroxy-2-methylpropanenitrile	-	Hevea brasiliensis	acetone + HCN	-	r
3-[(1S)-1-hydroxy-2-nitroethyl]phenol	enantiomeric excess: ~90%, yield: 60-70%	Hevea brasiliensis	3-hydroxybenzaldehyde + CH3NO2	-	r

Synonyms

Synonyms	Comment	Organism
HbHNL	-	Hevea brasiliensis
HNL	-	Hevea brasiliensis
Hydroxynitrile lyase	-	Hevea brasiliensis

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Release 2023.1 (January 2023)