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Literature summary for 4.1.2.47 extracted from

  • Zuegg, J.; Gruber, K.; Gugganig, M.; Wagner, U.G.; Kratky, C.
    Three-dimensional structures of enzyme-substrate complexes of the hydroxynitrile lyase from Hevea brasiliensis (1999), Protein Sci., 8, 1990-2000.
    View publication on PubMedView publication on EuropePMC
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Crystallization (Commentary)

Crystallization (Comment) Organism
enzyme in complex with acetone, hexafluoroacetone, trichloroacetaldehyde or rhodanine, hanging-drop vapour diffusion method, space group C222(1) Hevea brasiliensis

Inhibitors

Inhibitors Comment Organism Structure
acetone
-
 Hevea brasiliensis
hexafluoroacetone
-
 Hevea brasiliensis
rhodanide very strong competitive inhibitor Hevea brasiliensis
trichloracetaldehyde
-
 Hevea brasiliensis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2-hydroxy-2-methylpropanenitrile Hevea brasiliensis release of HCN serves as a defense against herbivores and microbial attack of the plant acetone + HCN
-
 ?

Organism

Organism UniProt Comment Textmining
Hevea brasiliensis
-
 tropical rubber tree
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-hydroxy-2-methylpropanenitrile release of HCN serves as a defense against herbivores and microbial attack of the plant Hevea brasiliensis acetone + HCN
-
 ?
2-hydroxyisobutyronitrile
-
 Hevea brasiliensis HCN + acetone
-
 ?
mandelonitrile racemic Hevea brasiliensis HCN + benzaldehyde
-
 ?

Synonyms

Synonyms Comment Organism
Hb-HNL
-
 Hevea brasiliensis
HNL
-
 Hevea brasiliensis