Literature summary for 4.1.2.27 extracted from

Ceccom, J.; Loukh, N.; Lauwers-Cances, V.; Touriol, C.; Nicaise, Y.; Gentil, C.; Uro-Coste, E.; Pitson, S.; Maurage, C.A.; Duyckaerts, C.; Cuvillier, O.; Delisle, M.B.
Reduced sphingosine kinase-1 and enhanced sphingosine 1-phosphate lyase expression demonstrate deregulated sphingosine 1-phosphate signaling in Alzheimers disease (2014), Acta Neuropathol. Commun., 2, 12 .

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
sphinganine 1-phosphate	Homo sapiens	-	phosphoethanolamine + palmitaldehyde	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain cortex cell line	-	Homo sapiens	-
hippocampus	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
sphinganine 1-phosphate	-	Homo sapiens	phosphoethanolamine + palmitaldehyde	-	?

Subunits

Subunits	Comment	Organism
?	x * 75000, SDS-PAGE	Homo sapiens

Synonyms

Synonyms	Comment	Organism
sphingosine 1-phosphate lyase	-	Homo sapiens
SPL	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	enzyme expression is increased in brains of patients with Alzheimer's disease	up

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Release 2023.1 (January 2023)