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Literature summary for 4.1.2.27 extracted from

  • Bourquin, F.; Capitani, G.; Gruetter, M.G.
    PLP-dependent enzymes as entry and exit gates of sphingolipid metabolism (2011), Protein Sci., 20, 1492-1508.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.1.2.27

Protein Variants

Protein Variants Comment Organism
H129A the mutation drastically impairs enzyme activity Saccharomyces cerevisiae
H129A the mutation drastically impairs enzyme activity Symbiobacterium thermophilum
Y105F inactive Saccharomyces cerevisiae
Y174F the mutant is partially active Saccharomyces cerevisiae

Inhibitors

Inhibitors Comment Organism Structure
1-deoxydihydrosphingosine 1-phosphonate
-
 Homo sapiens
1-deoxydihydrosphingosine 1-phosphonate
-
 Myxococcus xanthus
1-deoxydihydrosphingosine 1-phosphonate
-
 Saccharomyces cerevisiae
1-deoxydihydrosphingosine 1-phosphonate
-
 Symbiobacterium thermophilum
2-acetyl-4-tetrahydroxybutyl-imidazole
-
 Homo sapiens
2-acetyl-4-tetrahydroxybutyl-imidazole
-
 Myxococcus xanthus
2-acetyl-4-tetrahydroxybutyl-imidazole
-
 Saccharomyces cerevisiae
2-acetyl-4-tetrahydroxybutyl-imidazole
-
 Symbiobacterium thermophilum
2-vinyldihydro-sphingosine 1-phosphate
-
 Homo sapiens
2-vinyldihydro-sphingosine 1-phosphate
-
 Myxococcus xanthus
2-vinyldihydro-sphingosine 1-phosphate
-
 Saccharomyces cerevisiae
2-vinyldihydro-sphingosine 1-phosphate
-
 Symbiobacterium thermophilum
Ca2+
-
 Homo sapiens
Ca2+
-
 Myxococcus xanthus
Ca2+
-
 Saccharomyces cerevisiae
Ca2+
-
 Symbiobacterium thermophilum
FTY720 also called fingolimod Homo sapiens
FTY720 also called fingolimod Myxococcus xanthus
FTY720 also called fingolimod Saccharomyces cerevisiae
FTY720 also called fingolimod Symbiobacterium thermophilum
LX2931
-
 Homo sapiens
LX2931
-
 Myxococcus xanthus
LX2931
-
 Saccharomyces cerevisiae
LX2931
-
 Symbiobacterium thermophilum
threo-dihydro-sphingosine 1-phosphate
-
 Homo sapiens
threo-dihydro-sphingosine 1-phosphate
-
 Myxococcus xanthus
threo-dihydro-sphingosine 1-phosphate
-
 Saccharomyces cerevisiae
threo-dihydro-sphingosine 1-phosphate
-
 Symbiobacterium thermophilum
Zn2+
-
 Homo sapiens
Zn2+
-
 Myxococcus xanthus
Zn2+
-
 Saccharomyces cerevisiae
Zn2+
-
 Symbiobacterium thermophilum

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Homo sapiens 16020
-
membrane
-
 Saccharomyces cerevisiae 16020
-
membrane
-
 Myxococcus xanthus 16020
-
membrane
-
 Symbiobacterium thermophilum 16020
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Myxococcus xanthus
-
-
-
Saccharomyces cerevisiae
-
-
-
Symbiobacterium thermophilum
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
colon
-
 Homo sapiens
-
intestine
-
 Homo sapiens
-
liver
-
 Homo sapiens
-
additional information the human SGPL1 gene is ubiquitously expressed with the exception of erythrocytes and platelets and its expression is linked to tissues undergoing rapid cell turnover Homo sapiens
-
thymus
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
sphingosine 1-phosphate
-
 Homo sapiens phosphoethanolamine + (2E)-hexadecenal
-
 ir
sphingosine 1-phosphate
-
 Saccharomyces cerevisiae phosphoethanolamine + (2E)-hexadecenal
-
 ir
sphingosine 1-phosphate
-
 Myxococcus xanthus phosphoethanolamine + (2E)-hexadecenal
-
 ir
sphingosine 1-phosphate
-
 Symbiobacterium thermophilum phosphoethanolamine + (2E)-hexadecenal
-
 ir

Synonyms

Synonyms Comment Organism
Dpl1p
-
 Saccharomyces cerevisiae
sphingosine-1-phosphate lyase
-
 Homo sapiens
sphingosine-1-phosphate lyase
-
 Saccharomyces cerevisiae
sphingosine-1-phosphate lyase
-
 Myxococcus xanthus
sphingosine-1-phosphate lyase
-
 Symbiobacterium thermophilum
SPL
-
 Homo sapiens
SPL
-
 Saccharomyces cerevisiae
SPL
-
 Myxococcus xanthus
SPL
-
 Symbiobacterium thermophilum

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate dependent on Homo sapiens
pyridoxal 5'-phosphate dependent on Saccharomyces cerevisiae
pyridoxal 5'-phosphate dependent on Myxococcus xanthus
pyridoxal 5'-phosphate dependent on Symbiobacterium thermophilum

Expression

Organism Comment Expression
Homo sapiens SGPL1 gene expression is downregulated in colon cancer and is upregulated in certain malignant tissues, for example, in ovarian cancers as well as in the skin of patients suffering from atopic dermatitis down

General Information

General Information Comment Organism
metabolism SPL functions as the exit gate of the sphingolipid metabolism Homo sapiens
metabolism SPL functions as the exit gate of the sphingolipid metabolism Saccharomyces cerevisiae
metabolism SPL functions as the exit gate of the sphingolipid metabolism Myxococcus xanthus
metabolism SPL functions as the exit gate of the sphingolipid metabolism Symbiobacterium thermophilum
physiological function SPL plays a crucial role in the migration of T-cells from lymphoid tissues by maintaining the sphingosine 1-phosphate gradient necessary for T-cells to egress from the lymph nodes into the blood stream. SPL plays a central role in neutrophil egress from blood to tissues. SPL is a central and crucial regulator of lipid homeostasis. SPL activity is linked to an increase in CER levels in response to stress factors and is involved in apoptosis Homo sapiens