Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli | Symbiobacterium thermophilum |
Protein Variants | Comment | Organism |
---|---|---|
K311A | inactive | Symbiobacterium thermophilum |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
55000 | - |
x * 55000, SDS-PAGE | Symbiobacterium thermophilum |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Symbiobacterium thermophilum | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Symbiobacterium thermophilum |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
sphingosine 1-phosphate | SPL from Symbiobacterium thermophilum degrades extracellular sphingosine 1-phosphate in vitro and in blood | Symbiobacterium thermophilum | phosphoethanolamine + (2E)-hexadecenal | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 55000, SDS-PAGE | Symbiobacterium thermophilum |
Synonyms | Comment | Organism |
---|---|---|
S1P lyase | - |
Symbiobacterium thermophilum |
SPL | - |
Symbiobacterium thermophilum |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
pyridoxal 5'-phosphate | - |
Symbiobacterium thermophilum |
General Information | Comment | Organism |
---|---|---|
physiological function | in renal mesangial cells, endothelial cells, breast (MCF-7) and colon (HCT 116) carcinoma cells, wild type SPL from Symbiobacterium thermophilum disrupts MAPK phosphorylation stimulated by exogenous sphingosine 1-phosphate. Under in vivo conditions SPL from Symbiobacterium thermophilum inhibits tumor cell-induced angiogenesis as an sphingosine 1-phosphate-dependent process | Symbiobacterium thermophilum |