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Literature summary for 4.1.2.27 extracted from

  • Kumar, A.; Oskouian, B.; Fyrst, H.; Zhang, M.; Paris, F.; Saba, J.D.
    S1P lyase regulates DNA damage responses through a novel sphingolipid feedback mechanism (2011), Cell Death Dis., 2, e119.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.1.2.27

Organism

Organism UniProt Comment Textmining
Mus musculus
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
NIH-3T3 cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
sphingosine 1-phosphate
-
 Mus musculus phosphoethanolamine + (2E)-hexadecenal
-
 ir

Synonyms

Synonyms Comment Organism
S1P lyase
-
 Mus musculus
SPL
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
 Mus musculus

General Information

General Information Comment Organism
malfunction downregulation/inhibition of SPL prevents premature cell cycle progression and mitotic death. Oral administration of an SPL inhibitor to mice prolonges their survival after exposure to a lethal dose (10Gy) of total body ionizing radiation Mus musculus
metabolism S1P lyase catalyzes the irreversible degradation of sphingosine 1-phosphate in the final step of sphingolipid metabolism Mus musculus
physiological function SPL modulates the kinetics of DNA repair, speed of recovery from G2 cell cycle arrest and the extent of apoptosis after ionizing radiation. SPL expression affects the Cdk1-cyclin B complex Mus musculus