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Literature summary for 4.1.2.27 extracted from

  • Berdyshev, E.V.; Goya, J.; Gorshkova, I.; Prestwich, G.D.; Byun, H.S.; Bittman, R.; Natarajan, V.
    Characterization of sphingosine-1-phosphate lyase activity by electrospray ionization-liquid chromatography/tandem mass spectrometry quantitation of (2E)-hexadecenal (2011), Anal. Biochem., 408, 12-18.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.1.2.27

Inhibitors

Inhibitors Comment Organism Structure
FTY720 40% inhibition at 0.03 mM Mus musculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0057
-
 sphingosine 1-phosphate in 35 mM potassium phosphate buffer (pH 7.4), 0.6 mM EDTA, 70 mM sucrose, 36 mM sodium fluoride, 0.57 mM pyridoxal 5'-phosphate, at 37°C Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Mus musculus
-
-

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
sphingosine 1-phosphate
-
 Mus musculus phosphoethanolamine + (2E)-hexadecenal
-
 ir
sphingosine-1-phosphate
-
 Mus musculus phosphoethanolamine + (2E)-hexadecenal
-
 ir

Synonyms

Synonyms Comment Organism
S1P lyase
-
 Mus musculus
S1PL
-
 Mus musculus
sphingosine-1-phosphate lyase
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
 Mus musculus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0524
-
 in 35 mM potassium phosphate buffer (pH 7.4), 0.6 mM EDTA, 70 mM sucrose, 36 mM sodium fluoride, 0.57 mM pyridoxal 5'-phosphate, at 37°C Mus musculus FTY720