Application | Comment | Organism |
---|---|---|
medicine | S1P lyase is a therapeutic target for ischemia-reperfusion injury of the heart | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-{5-[(1R,2S,3R)-1,2,3,4-tetrahydroxybutyl]-1H-imidazol-2-yl}ethanone | when given overnight at 25 mg/l in drinking water, tetrahydroxybutylimidazole raises sphingosine 1-phosphate levels and reduces SPL activity | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
heart | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
omega-(7-nitro-2-1,3-benzoxadiazol-4-yl)-D-erythro-sphingosine 1-phosphate | - |
Mus musculus | phosphoethanolamine + omega-(7-nitro-2-1,3-benzoxadiazol-4-yl)-D-erythro-(2E)-hexadecenal | - |
ir |
Synonyms | Comment | Organism |
---|---|---|
S1P lyase | - |
Mus musculus |
SPL | - |
Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
pyridoxal 5'-phosphate | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | basal SPL activity is low in wild type cardiac tissue but is activated 3fold in response to 50 min of ischemia | up |
General Information | Comment | Organism |
---|---|---|
malfunction | hearts of heterozygous SPL knockout mice exhibit reduced SPL activity, elevated sphingosine 1-phosphate levels, smaller infarct size, and increased functional recovery after ischemia-reperfusion injury compared with littermate controls | Mus musculus |
physiological function | SPL contributes to oxidative stress by depleting sphingosine 1-phosphate pools available for cardioprotective signaling | Mus musculus |