BRENDA - Reference to 4.1.2.27; Id = 682957

2-acetyl-4-tetrahydroxybutylimidazole

-

Homo sapiens

2-acetyl-4-tetrahydroxybutylimidazole

-

Caenorhabditis elegans

2-acetyl-4-tetrahydroxybutylimidazole

-

Drosophila melanogaster

2-acetyl-4-tetrahydroxybutylimidazole

-

Mus musculus

2-acetyl-4-tetrahydroxybutylimidazole

-

Rattus norvegicus

bisulfite

-

Rattus norvegicus

bisulfite

-

Caenorhabditis elegans

bisulfite

-

Drosophila melanogaster

bisulfite

-

Homo sapiens

bisulfite

-

Mus musculus

cyanide

-

Caenorhabditis elegans

cyanide

-

Drosophila melanogaster

cyanide

-

Homo sapiens

cyanide

-

Mus musculus

cyanide

-

Rattus norvegicus

cysteine

-

Rattus norvegicus

cysteine

-

Caenorhabditis elegans

cysteine

-

Drosophila melanogaster

cysteine

-

Homo sapiens

cysteine

-

Mus musculus

deoxypyridoxine

competitive inhibitor

Caenorhabditis elegans

deoxypyridoxine

competitive inhibitor

Drosophila melanogaster

deoxypyridoxine

competitive inhibitor

Homo sapiens

deoxypyridoxine

competitive inhibitor

Mus musculus

deoxypyridoxine

competitive inhibitor

Rattus norvegicus

FTY720

-

Homo sapiens

FTY720

-

Caenorhabditis elegans

FTY720

-

Drosophila melanogaster

FTY720

-

Mus musculus

FTY720

-

Rattus norvegicus

Semicarbazide

-

Rattus norvegicus

Semicarbazide

-

Caenorhabditis elegans

Semicarbazide

-

Drosophila melanogaster

Semicarbazide

-

Homo sapiens

Semicarbazide

-

Mus musculus

endoplasmic reticulum

-

Homo sapiens

5783

-

endoplasmic reticulum

-

Mus musculus

5783

-

endoplasmic reticulum

-

Caenorhabditis elegans

5783

-

endoplasmic reticulum

-

Drosophila melanogaster

5783

-

endoplasmic reticulum

-

Rattus norvegicus

5783

-

microsome

-

Rattus norvegicus

-

microsome

-

Mus musculus

-

microsome

-

Caenorhabditis elegans

-

microsome

-

Drosophila melanogaster

-

microsome

-

Homo sapiens

-

mitochondrion

-

Caenorhabditis elegans

5739

-

mitochondrion

-

Drosophila melanogaster

5739

-

mitochondrion

-

Homo sapiens

5739

-

mitochondrion

-

Mus musculus

5739

-

mitochondrion

-

Rattus norvegicus

5739

-

63500

-

SDS-PAGE

Homo sapiens

Caenorhabditis elegans

-

Dictyostelium discoideum

-

Drosophila melanogaster

-

Homo sapiens

-

Leishmania major

-

Mus musculus

-

Rattus norvegicus

-

brain

-

Rattus norvegicus

-

brain

-

Mus musculus

-

colon

-

Mus musculus

-

colon

-

Rattus norvegicus

-

gut

-

Caenorhabditis elegans

-

gut

-

Drosophila melanogaster

-

heart

-

Rattus norvegicus

-

heart

-

Mus musculus

-

liver

-

Rattus norvegicus

-

liver

-

Mus musculus

-

lymphocyte

-

Homo sapiens

-

small intestine

-

Mus musculus

-

small intestine

-

Rattus norvegicus

-

thymus

-

Mus musculus

-

thymus

-

Homo sapiens

-

thymus

-

Rattus norvegicus

-

Sphingosine 1-phosphate

-

682957

Drosophila melanogaster

Phosphoethanolamine + palmitaldehyde

-

ir

Sphingosine 1-phosphate

-

682957

Mus musculus

Phosphoethanolamine + palmitaldehyde

-

ir

Sphingosine 1-phosphate

-

682957

Rattus norvegicus

Phosphoethanolamine + palmitaldehyde

-

ir

Sphingosine 1-phosphate

-

682957

Dictyostelium discoideum

Phosphoethanolamine + palmitaldehyde

-

ir

Sphingosine 1-phosphate

-

682957

Caenorhabditis elegans

Phosphoethanolamine + palmitaldehyde

-

ir

Sphingosine 1-phosphate

-

682957

Leishmania major

Phosphoethanolamine + palmitaldehyde

-

ir

sphingosine-1-phosphate lyase

-

Caenorhabditis elegans

sphingosine-1-phosphate lyase

-

Dictyostelium discoideum

sphingosine-1-phosphate lyase

-

Drosophila melanogaster

sphingosine-1-phosphate lyase

-

Leishmania major

sphingosine-1-phosphate lyase

-

Homo sapiens

sphingosine-1-phosphate lyase

-

Mus musculus

sphingosine-1-phosphate lyase

-

Rattus norvegicus

SPL

-

Caenorhabditis elegans

SPL

-

Dictyostelium discoideum

SPL

-

Drosophila melanogaster

SPL

-

Leishmania major

SPL

-

Homo sapiens

SPL

-

Rattus norvegicus

SPL

-

Mus musculus

pyridoxal 5'-phosphate

-

Rattus norvegicus

pyridoxal 5'-phosphate

-

Mus musculus

pyridoxal 5'-phosphate

-

Homo sapiens

pyridoxal 5'-phosphate

-

Caenorhabditis elegans

pyridoxal 5'-phosphate

-

Dictyostelium discoideum

pyridoxal 5'-phosphate

-

Drosophila melanogaster

pyridoxal 5'-phosphate

-

Leishmania major

pyridoxal 5'-phosphate

-

Rattus norvegicus

pyridoxal 5'-phosphate

-

Mus musculus

pyridoxal 5'-phosphate

-

Homo sapiens

pyridoxal 5'-phosphate

-

Caenorhabditis elegans

pyridoxal 5'-phosphate

-

Dictyostelium discoideum

pyridoxal 5'-phosphate

-

Drosophila melanogaster

pyridoxal 5'-phosphate

-

Leishmania major

2-acetyl-4-tetrahydroxybutylimidazole

-

Caenorhabditis elegans

2-acetyl-4-tetrahydroxybutylimidazole

-

Drosophila melanogaster

2-acetyl-4-tetrahydroxybutylimidazole

-

Homo sapiens

2-acetyl-4-tetrahydroxybutylimidazole

-

Mus musculus

2-acetyl-4-tetrahydroxybutylimidazole

-

Rattus norvegicus

bisulfite

-

Rattus norvegicus

bisulfite

-

Caenorhabditis elegans

bisulfite

-

Drosophila melanogaster

bisulfite

-

Homo sapiens

bisulfite

-

Mus musculus

cyanide

-

Caenorhabditis elegans

cyanide

-

Drosophila melanogaster

cyanide

-

Homo sapiens

cyanide

-

Mus musculus

cyanide

-

Rattus norvegicus

cysteine

-

Rattus norvegicus

cysteine

-

Caenorhabditis elegans

cysteine

-

Drosophila melanogaster

cysteine

-

Homo sapiens

cysteine

-

Mus musculus

deoxypyridoxine

competitive inhibitor

Caenorhabditis elegans

deoxypyridoxine

competitive inhibitor

Drosophila melanogaster

deoxypyridoxine

competitive inhibitor

Homo sapiens

deoxypyridoxine

competitive inhibitor

Mus musculus

deoxypyridoxine

competitive inhibitor

Rattus norvegicus

FTY720

-

Homo sapiens

FTY720

-

Caenorhabditis elegans

FTY720

-

Drosophila melanogaster

FTY720

-

Mus musculus

FTY720

-

Rattus norvegicus

Semicarbazide

-

Rattus norvegicus

Semicarbazide

-

Caenorhabditis elegans

Semicarbazide

-

Drosophila melanogaster

Semicarbazide

-

Homo sapiens

Semicarbazide

-

Mus musculus

endoplasmic reticulum

-

Homo sapiens

5783

-

endoplasmic reticulum

-

Mus musculus

5783

-

endoplasmic reticulum

-

Caenorhabditis elegans

5783

-

endoplasmic reticulum

-

Drosophila melanogaster

5783

-

endoplasmic reticulum

-

Rattus norvegicus

5783

-

microsome

-

Rattus norvegicus

-

microsome

-

Mus musculus

-

microsome

-

Caenorhabditis elegans

-

microsome

-

Drosophila melanogaster

-

microsome

-

Homo sapiens

-

mitochondrion

-

Caenorhabditis elegans

5739

-

mitochondrion

-

Drosophila melanogaster

5739

-

mitochondrion

-

Homo sapiens

5739

-

mitochondrion

-

Mus musculus

5739

-

mitochondrion

-

Rattus norvegicus

5739

-

63500

-

SDS-PAGE

Homo sapiens

brain

-

Rattus norvegicus

-

brain

-

Mus musculus

-

colon

-

Mus musculus

-

colon

-

Rattus norvegicus

-

gut

-

Caenorhabditis elegans

-

gut

-

Drosophila melanogaster

-

heart

-

Rattus norvegicus

-

heart

-

Mus musculus

-

liver

-

Rattus norvegicus

-

liver

-

Mus musculus

-

lymphocyte

-

Homo sapiens

-

small intestine

-

Mus musculus

-

small intestine

-

Rattus norvegicus

-

thymus

-

Mus musculus

-

thymus

-

Homo sapiens

-

thymus

-

Rattus norvegicus

-

Sphingosine 1-phosphate

-

682957

Drosophila melanogaster

Phosphoethanolamine + palmitaldehyde

-

ir

Sphingosine 1-phosphate

-

682957

Mus musculus

Phosphoethanolamine + palmitaldehyde

-

ir

Sphingosine 1-phosphate

-

682957

Rattus norvegicus

Phosphoethanolamine + palmitaldehyde

-

ir

Sphingosine 1-phosphate

-

682957

Dictyostelium discoideum

Phosphoethanolamine + palmitaldehyde

-

ir

Sphingosine 1-phosphate

-

682957

Caenorhabditis elegans

Phosphoethanolamine + palmitaldehyde

-

ir

Sphingosine 1-phosphate

-

682957

Leishmania major

Phosphoethanolamine + palmitaldehyde

-

ir

747511

Sanllehi

The first fluorogenic sensor ...

Homo sapiens

Chem. Commun. (Camb.)

53

5441-5444

2017

-

1

-

1

-

1

-

3

-

2

-

1

-

1

-

3

-

748220

Hahn

Overexpression of sphingosine ...

Rattus norvegicus

J. Biol. Chem.

292

20292-20304

2017

-

1

-

1

-

11

-

1

3

-

1

-

11

-

1

-

1

-

748365

McLean

Characterization of homologou ...

Burkholderia pseudomallei, Burkholderia pseudomallei K96243

J. Lipid Res.

58

137-150

2017

-

1

-

2

-

2

-

6

-

1

-

6

-

4

-

2

-

1

-

1

-

2

-

2

-

1

-

6

-

2

-

1

747275

Dinges

Hit-to-lead evaluation of a n ...

Homo sapiens

Bioorg. Med. Chem. Lett.

26

2297-2302

2016

-

23

-

1

-

1

-

1

-

2

-

1

-

20

-

1

-

20

23

-

1

-

1

-

747522

Suh

A facile stable-isotope dilut ...

Homo sapiens, Mus musculus

Chem. Phys. Lipids

194

101-109

2016

-

2

-

2

-

3

-

3

-

2

-

4

-

2

-

2

-

3

-

2

-

747523

Sanllehi

Inhibitors of sphingosine-1-p ...

Homo sapiens

Chem. Phys. Lipids

197

69-81

2016

-

9

-

1

-

1

-

1

-

1

-

2

-

1

-

2

-

1

-

2

9

1

-

1

-

1

-

1

-

747694

Sanllehi

Studies on the inhibition of ...

Homo sapiens, Symbiobacterium thermophilum

Eur. J. Med. Chem.

123

905-915

2016

-

28

-

1

-

2

-

3

-

4

-

4

-

2

10

-

24

-

2

-

24

28

10

-

1

-

2

-

4

-

748338

Zamora-Pineda

Dendritic cell sphingosine-1- ...

Mus musculus

J. Exp. Med.

213

2773-2791

2016

-

1

-

2

-

8

-

1

3

-

1

-

8

-

1

-

1

-

748668

Custodio

Characterization of secreted ...

Burkholderia pseudomallei, Burkholderia pseudomallei K96243, Burkholderia thailandensis

Mol. Microbiol.

102

1004-1019

2016

-

2

-

3

-

9

-

3

2

6

-

2

-

3

-

3

2

-

4

-

749075

Abu Khweek

The sphingosine-1-phosphate l ...

Legionella pneumophila, Legionella pneumophila JR32

PLoS ONE

11

e0146410

2016

-

2

-

8

-

2

-

2

-

2

-

2

-

2

-

2

-

1

-

748649

Ohtoyo

Sphingosine 1-phosphate lyase ...

Mus musculus

Mol. Cell. Biochem.

400

125-133

2015

-

2

-

1

-

2

-

1

-

1

-

2

-

1

-

1

-

2

-

1

-

1

-

1

-

749402

Schuemann

Reduced activity of sphingosi ...

Mus musculus, Rattus norvegicus

Toxicol. Pathol.

43

694-703

2015

-

2

-

2

-

7

-

2

-

4

-

2

-

2

-

2

-

2

-

727280

Gatfield

Sphingosine-1-phosphate (S1P) ...

Homo sapiens

Cell. Signal.

26

1576-1588

2014

-

1

-

3

-

1

-

1

-

1

-

727416

Park

Sphingosine-1-phosphate lyase ...

Homo sapiens

Eur. J. Immunol.

44

2425-2436

2014

-

3

-

3

-

3

-

727464

de la Garza-Rodea

Sphingosine phosphate lyase re ...

Mus musculus

FASEB J.

28

506-519

2014

-

2

-

1

-

1

-

1

-

1

-

746682

Ceccom

Reduced sphingosine kinase-1 ...

Homo sapiens

Acta Neuropathol. Commun.

2

12

2014

-

1

-

1

-

2

-

1

2

-

1

-

2

-

1

-

1

-

1

-

748366

Weiler

Orally active 7-substituted [ ...

Homo sapiens

J. Med. Chem.

57

5074-5084

2014

-

1

-

23

-

1

-

4

-

1

-

1

3

-

19

-

1

-

1

-

19

23

-

1

-

1

-

1

-

748935

Zhang

Molecular characterization of ...

Oryza sativa

Plant Cell Rep.

33

1745-1756

2014

-

1

-

1

-

7

-

1

-

1

-

2

-

1

-

1

-

1

-

1

-

2

-

2

-

726675

Billich

Cellular assay for the charact ...

Homo sapiens

Anal. Biochem.

434

247-253

2013

-

1

-

1

-

2

-

1

-

2

-

1

-

727130

Smith

Sphingosine phosphate lyase re ...

Mus musculus

Biomolecules

3

351-368

2013

-

2

-

2

-

2

-

1

-

728597

Billich

Partial deficiency of sphingos ...

Mus musculus

PLoS ONE

8

e59630

2013

-

1

-

2

-

1

-

1

-

727299

Reina

Determination of sphingosine-1 ...

Mus musculus

Chem. Phys. Lipids

165

225-231

2012

-

1

-

2

1

-

2

-

1

-

2

-

1

-

2

-

1

-

1

-

2

-

728089

Borowsky

Sphingosine-1-phosphate lyase ...

Mus musculus

J. Lipid Res.

53

1920-1931

2012

-

2

-

15

-

15

-

728291

Brizuela

First evidence of sphingosine ...

Homo sapiens

Mol. Cancer Ther.

11

1841-1851

2012

-

1

-

2

-

4

-

1

-

4

-

1

-

713721

Bandhuvula

S1P lyase: a novel therapeutic ...

Mus musculus

Am. J. Physiol. Heart Circ. Physiol.

300

H1753-H1761

2011

-

1

-

1

-

3

-

1

-

1

-

2

-

1

-

1

-

1

-

1

-

1

-

1

-

1

2

1

-

713741

Berdyshev

Characterization of sphingosin ...

Mus musculus

Anal. Biochem.

408

12-18

2011

-

1

-

1

-

2

-

3

-

1

-

1

-

1

-

1

-

1

-

2

-

714336

Ito

Heterogeneous sphingosine-1-ph ...

Homo sapiens

Biochim. Biophys. Acta

1811

119-128

2011

-

2

-

3

-

6

-

1

3

-

1

-

1

-

2

-

6

-

1

-

1

-

1

-

714674

Kumar

S1P lyase regulates DNA damage ...

Mus musculus

Cell Death Dis.

2

e119

2011

-

3

-

1

-

1

-

2

-

1

-

1

-

1

-

1

-

3

-

716696

Berdyshev

Intracellular S1P generation i ...

Homo sapiens

PLoS ONE

6

e16571

2011

-

1

-

1

-

2

-

4

-

1

-

3

-

1

-

1

-

1

-

1

-

4

-

1

-

1

-

716716

Huwiler

A prokaryotic S1P lyase degrad ...

Symbiobacterium thermophilum

PLoS ONE

6

e22436

2011

-

1

-

1

-

1

-

5

-

1

-

1

2

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

716860

Bourquin

PLP-dependent enzymes as entry ...

Homo sapiens, Myxococcus xanthus, Saccharomyces cerevisiae, Symbiobacterium thermophilum

Protein Sci.

20

1492-1508

2011

-

4

-

32

-

4

-

5

-

5

-

4

-

9

-

4

-

4

-

4

-

32

-

4

-

5

-

4

-

1

5

1

-

707340

Colie

Regulation of cell death by sp ...

Mus musculus

Autophagy

6

426-427

2010

-

1

-

1

-

1

-

1

-

1

-

1

-

707641

Dunlap

The sphingosine 1-phosphate (S ...

Ovis aries

Biol. Reprod.

82

876-887

2010

-

4

-

1

-

1

-

708071

Claas

Enhanced Ca2+ storage in sphin ...

Mus musculus

Cell. Signal.

22

476-483

2010

-

2

-

2

-

2

-

1

-

709085

Bektas

Sphingosine 1-phosphate lyase ...

Mus musculus

J. Biol. Chem.

285

10880-10889

2010

-

2

-

1

-

710689

Yu

Pharmacokinetic/pharmacodynami ...

Rattus norvegicus

Xenobiotica

40

350-356

2010

-

1

-

1

-

3

-

2

-

1

-

1

-

2

-

713688

Serra

Sphingosine 1-phosphate lyase, ...

Homo sapiens, Mus musculus, Rattus norvegicus

Adv. Enzyme Regul.

50

349-362

2010

-

18

-

3

-

3

-

3

-

16

-

12

3

15

-

3

-

3

-

18

-

3

-

3

-

16

-

12

3

-

3

-

716935

Bourquin

Structure and function of sphi ...

Homo sapiens, Saccharomyces cerevisiae, Symbiobacterium thermophilum

Structure

18

1054-1065

2010

-

2

-

3

-

6

-

2

-

3

7

-

3

-

2

3

2

-

3

-

2

-

3

-

3

-

707358

Bandhuvula

Sphingosine 1-phosphate lyase ...

Homo sapiens

Biochem. Biophys. Res. Commun.

380

366-370

2009

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

708817

Ling

Sphingosine-1-phosphate: a pot ...

Homo sapiens

Invest. New Drugs

29

396-399

2009

-

1

-

2

-

1

-

1

-

1

-

709004

Hagen

Subcellular origin of sphingos ...

Mus musculus

J. Biol. Chem.

284

11346-11353

2009

-

1

-

1

-

1

-

1

-

1

-

1

-

709358

Weber

Discontinued postnatal thymocy ...

Mus musculus

J. Immunol.

183

4292-4301

2009

-

1

-

2

-

1

-

1

-

709444

Bagdanoff

Inhibition of sphingosine-1-ph ...

Mus musculus

J. Med. Chem.

52

3941-3953

2009

-

4

-

2

-

1

-

4

-

1

-

710355

Vogel

Incomplete inhibition of sphin ...

Homo sapiens, Mus musculus

PLoS ONE

4

e4112

2009

-

2

1

-

5

-

2

1

-

2

-

681026

Peest

S1P-lyase independent clearanc ...

Homo sapiens

J. Cell. Biochem.

104

756-772

2008

-

1

-

3

-

1

-

1

-

1

-

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Sphingosine-1-phosphate lyase in immunity and cancer: silencing the siren

Data extracted from this reference: