BRENDA - Enzyme Database show
show all sequences of 4.1.2.27

Sphingosine-1-phosphate lyase in immunity and cancer: silencing the siren

Bandhuvula, P.; Saba, J.D.; Trends Mol. Med. 13, 210-217 (2007)

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
2-acetyl-4-tetrahydroxybutylimidazole
-
Caenorhabditis elegans
2-acetyl-4-tetrahydroxybutylimidazole
-
Drosophila melanogaster
2-acetyl-4-tetrahydroxybutylimidazole
-
Mus musculus
2-acetyl-4-tetrahydroxybutylimidazole
-
Rattus norvegicus
2-acetyl-4-tetrahydroxybutylimidazole
-
Homo sapiens
bisulfite
-
Caenorhabditis elegans
bisulfite
-
Drosophila melanogaster
bisulfite
-
Homo sapiens
bisulfite
-
Mus musculus
bisulfite
-
Rattus norvegicus
cyanide
-
Caenorhabditis elegans
cyanide
-
Drosophila melanogaster
cyanide
-
Homo sapiens
cyanide
-
Mus musculus
cyanide
-
Rattus norvegicus
cysteine
-
Caenorhabditis elegans
cysteine
-
Drosophila melanogaster
cysteine
-
Homo sapiens
cysteine
-
Mus musculus
cysteine
-
Rattus norvegicus
deoxypyridoxine
competitive inhibitor
Caenorhabditis elegans
deoxypyridoxine
competitive inhibitor
Drosophila melanogaster
deoxypyridoxine
competitive inhibitor
Homo sapiens
deoxypyridoxine
competitive inhibitor
Mus musculus
deoxypyridoxine
competitive inhibitor
Rattus norvegicus
FTY720
-
Caenorhabditis elegans
FTY720
-
Drosophila melanogaster
FTY720
-
Mus musculus
FTY720
-
Rattus norvegicus
FTY720
-
Homo sapiens
Semicarbazide
-
Caenorhabditis elegans
Semicarbazide
-
Drosophila melanogaster
Semicarbazide
-
Homo sapiens
Semicarbazide
-
Mus musculus
Semicarbazide
-
Rattus norvegicus
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
endoplasmic reticulum
-
Caenorhabditis elegans
5783
-
endoplasmic reticulum
-
Drosophila melanogaster
5783
-
endoplasmic reticulum
-
Rattus norvegicus
5783
-
endoplasmic reticulum
-
Mus musculus
5783
-
endoplasmic reticulum
-
Homo sapiens
5783
-
microsome
-
Caenorhabditis elegans
-
-
microsome
-
Drosophila melanogaster
-
-
microsome
-
Homo sapiens
-
-
microsome
-
Rattus norvegicus
-
-
microsome
-
Mus musculus
-
-
mitochondrion
-
Caenorhabditis elegans
5739
-
mitochondrion
-
Drosophila melanogaster
5739
-
mitochondrion
-
Homo sapiens
5739
-
mitochondrion
-
Mus musculus
5739
-
mitochondrion
-
Rattus norvegicus
5739
-
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
63500
-
SDS-PAGE
Homo sapiens
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Caenorhabditis elegans
-
-
-
Dictyostelium discoideum
-
-
-
Drosophila melanogaster
-
-
-
Homo sapiens
-
-
-
Leishmania major
-
-
-
Mus musculus
-
-
-
Rattus norvegicus
-
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
brain
-
Mus musculus
-
brain
-
Rattus norvegicus
-
colon
-
Mus musculus
-
colon
-
Rattus norvegicus
-
gut
-
Caenorhabditis elegans
-
gut
-
Drosophila melanogaster
-
heart
-
Mus musculus
-
heart
-
Rattus norvegicus
-
liver
-
Rattus norvegicus
-
liver
-
Mus musculus
-
lymphocyte
-
Homo sapiens
-
small intestine
-
Rattus norvegicus
-
small intestine
-
Mus musculus
-
thymus
-
Rattus norvegicus
-
thymus
-
Homo sapiens
-
thymus
-
Mus musculus
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Sphingosine 1-phosphate
-
682957
Drosophila melanogaster
Phosphoethanolamine + palmitaldehyde
-
-
-
ir
Sphingosine 1-phosphate
-
682957
Mus musculus
Phosphoethanolamine + palmitaldehyde
-
-
-
ir
Sphingosine 1-phosphate
-
682957
Rattus norvegicus
Phosphoethanolamine + palmitaldehyde
-
-
-
ir
Sphingosine 1-phosphate
-
682957
Dictyostelium discoideum
Phosphoethanolamine + palmitaldehyde
-
-
-
ir
Sphingosine 1-phosphate
-
682957
Caenorhabditis elegans
Phosphoethanolamine + palmitaldehyde
-
-
-
ir
Sphingosine 1-phosphate
-
682957
Leishmania major
Phosphoethanolamine + palmitaldehyde
-
-
-
ir
Cofactor
Cofactor
Commentary
Organism
Structure
pyridoxal 5'-phosphate
-
Caenorhabditis elegans
pyridoxal 5'-phosphate
-
Dictyostelium discoideum
pyridoxal 5'-phosphate
-
Drosophila melanogaster
pyridoxal 5'-phosphate
-
Leishmania major
pyridoxal 5'-phosphate
-
Rattus norvegicus
pyridoxal 5'-phosphate
-
Homo sapiens
pyridoxal 5'-phosphate
-
Mus musculus
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
pyridoxal 5'-phosphate
-
Caenorhabditis elegans
pyridoxal 5'-phosphate
-
Dictyostelium discoideum
pyridoxal 5'-phosphate
-
Drosophila melanogaster
pyridoxal 5'-phosphate
-
Leishmania major
pyridoxal 5'-phosphate
-
Rattus norvegicus
pyridoxal 5'-phosphate
-
Homo sapiens
pyridoxal 5'-phosphate
-
Mus musculus
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
2-acetyl-4-tetrahydroxybutylimidazole
-
Caenorhabditis elegans
2-acetyl-4-tetrahydroxybutylimidazole
-
Drosophila melanogaster
2-acetyl-4-tetrahydroxybutylimidazole
-
Homo sapiens
2-acetyl-4-tetrahydroxybutylimidazole
-
Mus musculus
2-acetyl-4-tetrahydroxybutylimidazole
-
Rattus norvegicus
bisulfite
-
Caenorhabditis elegans
bisulfite
-
Drosophila melanogaster
bisulfite
-
Homo sapiens
bisulfite
-
Mus musculus
bisulfite
-
Rattus norvegicus
cyanide
-
Caenorhabditis elegans
cyanide
-
Drosophila melanogaster
cyanide
-
Homo sapiens
cyanide
-
Mus musculus
cyanide
-
Rattus norvegicus
cysteine
-
Caenorhabditis elegans
cysteine
-
Drosophila melanogaster
cysteine
-
Homo sapiens
cysteine
-
Mus musculus
cysteine
-
Rattus norvegicus
deoxypyridoxine
competitive inhibitor
Caenorhabditis elegans
deoxypyridoxine
competitive inhibitor
Drosophila melanogaster
deoxypyridoxine
competitive inhibitor
Homo sapiens
deoxypyridoxine
competitive inhibitor
Mus musculus
deoxypyridoxine
competitive inhibitor
Rattus norvegicus
FTY720
-
Caenorhabditis elegans
FTY720
-
Drosophila melanogaster
FTY720
-
Mus musculus
FTY720
-
Rattus norvegicus
FTY720
-
Homo sapiens
Semicarbazide
-
Caenorhabditis elegans
Semicarbazide
-
Drosophila melanogaster
Semicarbazide
-
Homo sapiens
Semicarbazide
-
Mus musculus
Semicarbazide
-
Rattus norvegicus
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
endoplasmic reticulum
-
Caenorhabditis elegans
5783
-
endoplasmic reticulum
-
Drosophila melanogaster
5783
-
endoplasmic reticulum
-
Rattus norvegicus
5783
-
endoplasmic reticulum
-
Mus musculus
5783
-
endoplasmic reticulum
-
Homo sapiens
5783
-
microsome
-
Caenorhabditis elegans
-
-
microsome
-
Drosophila melanogaster
-
-
microsome
-
Homo sapiens
-
-
microsome
-
Rattus norvegicus
-
-
microsome
-
Mus musculus
-
-
mitochondrion
-
Caenorhabditis elegans
5739
-
mitochondrion
-
Drosophila melanogaster
5739
-
mitochondrion
-
Homo sapiens
5739
-
mitochondrion
-
Mus musculus
5739
-
mitochondrion
-
Rattus norvegicus
5739
-
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
63500
-
SDS-PAGE
Homo sapiens
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
brain
-
Mus musculus
-
brain
-
Rattus norvegicus
-
colon
-
Mus musculus
-
colon
-
Rattus norvegicus
-
gut
-
Caenorhabditis elegans
-
gut
-
Drosophila melanogaster
-
heart
-
Mus musculus
-
heart
-
Rattus norvegicus
-
liver
-
Rattus norvegicus
-
liver
-
Mus musculus
-
lymphocyte
-
Homo sapiens
-
small intestine
-
Rattus norvegicus
-
small intestine
-
Mus musculus
-
thymus
-
Rattus norvegicus
-
thymus
-
Homo sapiens
-
thymus
-
Mus musculus
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Sphingosine 1-phosphate
-
682957
Drosophila melanogaster
Phosphoethanolamine + palmitaldehyde
-
-
-
ir
Sphingosine 1-phosphate
-
682957
Mus musculus
Phosphoethanolamine + palmitaldehyde
-
-
-
ir
Sphingosine 1-phosphate
-
682957
Rattus norvegicus
Phosphoethanolamine + palmitaldehyde
-
-
-
ir
Sphingosine 1-phosphate
-
682957
Dictyostelium discoideum
Phosphoethanolamine + palmitaldehyde
-
-
-
ir
Sphingosine 1-phosphate
-
682957
Caenorhabditis elegans
Phosphoethanolamine + palmitaldehyde
-
-
-
ir
Sphingosine 1-phosphate
-
682957
Leishmania major
Phosphoethanolamine + palmitaldehyde
-
-
-
ir
Other publictions for EC 4.1.2.27
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
747511
Sanllehi
The first fluorogenic sensor ...
Homo sapiens
Chem. Commun. (Camb.)
53
5441-5444
2017
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
1
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
748220
Hahn
Overexpression of sphingosine ...
Rattus norvegicus
J. Biol. Chem.
292
20292-20304
2017
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
11
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
11
-
-
1
1
-
-
-
-
-
-
-
-
-
1
1
-
-
-
748365
McLean
Characterization of homologou ...
Burkholderia pseudomallei, Burkholderia pseudomallei K96243
J. Lipid Res.
58
137-150
2017
-
-
1
1
1
-
-
2
-
-
-
2
-
5
-
-
1
-
-
-
-
-
6
-
-
-
-
2
-
-
-
1
-
-
-
-
-
1
1
1
1
-
-
-
-
2
-
-
-
2
-
-
-
1
-
-
-
-
6
-
-
-
-
2
-
-
-
-
-
-
-
-
1
1
747275
Dinges
Hit-to-lead evaluation of a n ...
Homo sapiens
Bioorg. Med. Chem. Lett.
26
2297-2302
2016
-
-
-
-
-
-
23
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
20
-
-
-
1
-
-
-
20
23
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
747522
Suh
A facile stable-isotope dilut ...
Homo sapiens, Mus musculus
Chem. Phys. Lipids
194
101-109
2016
-
-
-
-
-
-
-
-
2
-
-
2
-
3
-
-
-
-
-
3
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
2
-
-
-
-
-
3
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
747523
Sanllehi
Inhibitors of sphingosine-1-p ...
Homo sapiens
Chem. Phys. Lipids
197
69-81
2016
-
-
-
-
-
-
9
-
1
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
1
-
2
-
-
-
1
-
-
-
2
9
1
-
1
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
747694
Sanllehi
Studies on the inhibition of ...
Homo sapiens, Symbiobacterium thermophilum
Eur. J. Med. Chem.
123
905-915
2016
-
-
-
-
-
-
28
-
1
-
-
2
-
3
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
2
10
-
24
-
-
-
2
-
-
-
24
28
10
-
1
-
-
2
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
748338
Zamora-Pineda
Dendritic cell sphingosine-1- ...
Mus musculus
J. Exp. Med.
213
2773-2791
2016
-
-
-
-
-
-
-
-
-
-
-
1
-
2
-
-
-
-
-
8
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
8
-
-
1
1
-
-
-
-
-
-
-
-
-
1
1
-
-
-
748668
Custodio
Characterization of secreted ...
Burkholderia pseudomallei, Burkholderia pseudomallei K96243, Burkholderia thailandensis
Mol. Microbiol.
102
1004-1019
2016
-
-
-
-
-
-
2
-
-
-
-
3
-
9
-
-
-
-
-
-
-
-
3
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
3
-
-
-
-
-
-
-
-
3
2
-
-
-
-
-
-
-
-
-
4
4
-
-
-
749075
Abu Khweek
The sphingosine-1-phosphate l ...
Legionella pneumophila, Legionella pneumophila JR32
PLoS ONE
11
e0146410
2016
-
-
-
-
-
-
-
-
-
-
-
2
-
8
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
748649
Ohtoyo
Sphingosine 1-phosphate lyase ...
Mus musculus
Mol. Cell. Biochem.
400
125-133
2015
-
-
-
-
-
-
2
-
-
-
-
1
-
2
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
749402
Schuemann
Reduced activity of sphingosi ...
Mus musculus, Rattus norvegicus
Toxicol. Pathol.
43
694-703
2015
-
-
-
-
-
-
2
-
-
-
-
2
-
7
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
727280
Gatfield
Sphingosine-1-phosphate (S1P) ...
Homo sapiens
Cell. Signal.
26
1576-1588
2014
-
1
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
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-
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-
-
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-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
727416
Park
Sphingosine-1-phosphate lyase ...
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