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Literature summary for 4.1.2.25 extracted from
- Validation of Mycobacterium tuberculosis dihydroneopterin aldolase as a molecular target for anti-tuberculosis drug development (2017), Biochem. Biophys. Res. Commun., 485, 814-819 .
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Escherichia coli BL21(DE3) cells | Mycobacterium tuberculosis |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| K99A | inactive | Mycobacterium tuberculosis |
| Y54F | inactive | Mycobacterium tuberculosis |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde | Mycobacterium tuberculosis | - |
7,8-dihydroneopterin + 7,8-dihydromonapterin | - |
r |  |
| 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde | Mycobacterium tuberculosis H37Rv | - |
7,8-dihydroneopterin + 7,8-dihydromonapterin | - |
r | |
| 7,8-dihydroneopterin | Mycobacterium tuberculosis | - |
6-(hydroxymethyl)-7,8-dihydropterin + glycolaldehyde | - |
r | |
| 7,8-dihydroneopterin | Mycobacterium tuberculosis H37Rv | - |
6-(hydroxymethyl)-7,8-dihydropterin + glycolaldehyde | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mycobacterium tuberculosis | P9WNG5 | - |
- |
| Mycobacterium tuberculosis H37Rv | P9WNG5 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Mycobacterium tuberculosis |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde | - |
Mycobacterium tuberculosis | 7,8-dihydroneopterin + 7,8-dihydromonapterin | - |
r | |
| 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde | - |
Mycobacterium tuberculosis H37Rv | 7,8-dihydroneopterin + 7,8-dihydromonapterin | - |
r | |
| 7,8-dihydroneopterin | - |
Mycobacterium tuberculosis | 6-(hydroxymethyl)-7,8-dihydropterin + glycolaldehyde | - |
r | |
| 7,8-dihydroneopterin | - |
Mycobacterium tuberculosis H37Rv | 6-(hydroxymethyl)-7,8-dihydropterin + glycolaldehyde | - |
r | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 14412, calculated from amino acid sequence | Mycobacterium tuberculosis |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| dihydroneopterin aldolase/epimerase | - |
Mycobacterium tuberculosis |
| FolB | - |
Mycobacterium tuberculosis |
| Rv3607c | - |
Mycobacterium tuberculosis |
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Release 2023.1 (January 2023)
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