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Literature summary for 4.1.2.25 extracted from
- An atypical orthologue of 6-pyruvoyltetrahydropterin synthase can provide the missing link in the folate biosynthesis pathway of malaria parasites (2008), Mol. Microbiol., 67, 609-618.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | drugs targeting folate metabolism have long been used as highly successful antimicrobial and anticancer agents | Escherichia coli |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 7,8-dihydroneopterin | Escherichia coli | - |
6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
BL21(DE3) | - |
| no activity in Plasmodium falciparum | - |
Plasmodium falciparum cell extracts have SHMT and PPPK-DHPS but not DHNA activities | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 7,8-dihydroneopterin | - |
Escherichia coli | 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| DHNA | - |
Escherichia coli |
| dihydroneopterin aldolase | - |
Escherichia coli |
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Release 2023.1 (January 2023)
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