BRENDA - Enzyme Database
show all sequences of 4.1.2.22

Crystal structure of Bifidobacterium longum phosphoketolase; key enzyme for glucose metabolism in Bifidobacterium

Takahashi, K.; Tagami, U.; Shimba, N.; Kashiwagi, T.; Ishikawa, K.; Suzuki, E.; FEBS Lett. 584, 3855-3861 (2010)

Data extracted from this reference:

Crystallization (Commentary)
Crystallization
Organism
using 10 mg/ml thiamine diphosphate, 4% (v/v) Tacsimate pH 5.0, 12% (w/v) polyethylene glycol 3350 for the native enzyme. Se-Met substituted protein crystals are grown with 17% (w/v) polyethylene glycol 3350, 0.1 M MES (pH6.6), 0.2 M sodium thiocyanate in the absence of thiamine diphosphate
Bifidobacterium longum
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
Ca2+
contains Ca2+ bound to the active site
Bifidobacterium longum
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
92500
-
2 * 92500, SDS-PAGE
Bifidobacterium longum
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Bifidobacterium longum
-
-
-
Bifidobacterium longum JCM 1217
-
-
-
Purification (Commentary)
Commentary
Organism
HisTrap column chromatography, MonoQ column chromatography, and Superdex 200 gel filtration
Bifidobacterium longum
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
D-Fructose 6-phosphate + phosphate
-
715026
Bifidobacterium longum
Acetyl phosphate + D-erythrose 4-phosphate + H2O
-
-
-
?
D-Fructose 6-phosphate + phosphate
-
715026
Bifidobacterium longum JCM 1217
Acetyl phosphate + D-erythrose 4-phosphate + H2O
-
-
-
?
D-xylulose 5-phosphate + phosphate
-
715026
Bifidobacterium longum
acetyl phosphate + D-glyceraldehyde 3-phosphate
-
-
-
?
D-xylulose 5-phosphate + phosphate
-
715026
Bifidobacterium longum JCM 1217
acetyl phosphate + D-glyceraldehyde 3-phosphate
-
-
-
?
Subunits
Subunits
Commentary
Organism
homodimer
2 * 92500, SDS-PAGE
Bifidobacterium longum
Cofactor
Cofactor
Commentary
Organism
Structure
thiamine diphosphate
dependent on
Bifidobacterium longum
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
thiamine diphosphate
dependent on
Bifidobacterium longum
Crystallization (Commentary) (protein specific)
Crystallization
Organism
using 10 mg/ml thiamine diphosphate, 4% (v/v) Tacsimate pH 5.0, 12% (w/v) polyethylene glycol 3350 for the native enzyme. Se-Met substituted protein crystals are grown with 17% (w/v) polyethylene glycol 3350, 0.1 M MES (pH6.6), 0.2 M sodium thiocyanate in the absence of thiamine diphosphate
Bifidobacterium longum
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
Ca2+
contains Ca2+ bound to the active site
Bifidobacterium longum
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
92500
-
2 * 92500, SDS-PAGE
Bifidobacterium longum
Purification (Commentary) (protein specific)
Commentary
Organism
HisTrap column chromatography, MonoQ column chromatography, and Superdex 200 gel filtration
Bifidobacterium longum
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
D-Fructose 6-phosphate + phosphate
-
715026
Bifidobacterium longum
Acetyl phosphate + D-erythrose 4-phosphate + H2O
-
-
-
?
D-Fructose 6-phosphate + phosphate
-
715026
Bifidobacterium longum JCM 1217
Acetyl phosphate + D-erythrose 4-phosphate + H2O
-
-
-
?
D-xylulose 5-phosphate + phosphate
-
715026
Bifidobacterium longum
acetyl phosphate + D-glyceraldehyde 3-phosphate
-
-
-
?
D-xylulose 5-phosphate + phosphate
-
715026
Bifidobacterium longum JCM 1217
acetyl phosphate + D-glyceraldehyde 3-phosphate
-
-
-
?
Subunits (protein specific)
Subunits
Commentary
Organism
homodimer
2 * 92500, SDS-PAGE
Bifidobacterium longum
Other publictions for EC 4.1.2.22
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
747623
Pechar
Classification of culturable ...
Bifidobacterium boum, Bifidobacterium boum LMG 10736, Bifidobacterium boum ST6, Bifidobacterium choerinum, Bifidobacterium choerinum LMG 10510, Bifidobacterium pseudolongum subsp. globosum, Bifidobacterium pseudolongum subsp. globosum JCM 5820, Bifidobacterium pseudolongum subsp. globosum ST7, Bifidobacterium pseudolongum subsp. pseudolongum, Bifidobacterium pseudolongum subsp. pseudolongum JCM 1205, Bifidobacterium sp. ST1, Bifidobacterium sp. ST2, Bifidobacterium sp. ST3, Bifidobacterium sp. ST4, Bifidobacterium sp. ST5, Bifidobacterium thermacidophilum subsp. thermacidophilum, Bifidobacterium thermacidophilum subsp. thermacidophilum DSM 15837, Bifidobacterium thermophilum, Bifidobacterium thermophilum AS 1.2235, Bifidobacterium thermophilum subsp. porcinum, Bifidobacterium thermophilum subsp. porcinum P3-14, Bifidobacterium thermophilum subsp. porcinum ST8, Bifidobacterium thermophilum subsp. porcinum ST9
Curr. Microbiol.
74
1324-1331
2017
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23
-
28
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23
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23
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23
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-
-
747991
Pechar
Bifidobacterium apri sp. nov. ...
Bifidobacterium apri, Bifidobacterium apri DSM 100238
Int. J. Syst. Evol. Microbiol.
67
2349-2356
2017
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2
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-
747992
Sechovcova
Alloscardovia venturai sp. no ...
Alloscardovia venturai, Alloscardovia venturai DSM 100237
Int. J. Syst. Evol. Microbiol.
67
2842-2847
2017
-
-
-
-
-
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-
-
2
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-
749102
Gupta
Novel molecular, structural a ...
Bifidobacterium animalis, Bifidobacterium bifidum, Bifidobacterium breve, Bifidobacterium longum, Bifidobacterium reuteri
PLoS ONE
12
e0172176
2017
-
-
-
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10
-
5
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10
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10
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10
-
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-
746713
Bergman
Functional expression and eva ...
Bifidobacterium adolescentis, Bifidobacterium animalis subsp. lactis, Bifidobacterium breve, Clostridium acetobutylicum, Lactobacillus plantarum, Leuconostoc mesenteroides
AMB Express
6
115
2016
-
6
6
-
-
-
-
-
-
-
-
-
-
7
-
-
-
-
-
-
-
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7
-
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7
7
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-
7
-
-
-
-
-
-
-
-
-
-
6
7
-
-
-
747315
Moriyama
Characterization of three put ...
Nostoc sp. PCC 7120
Biosci. Biotechnol. Biochem.
79
767-774
2015
-
-
-
-
-
-
-
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2
-
4
-
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1
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2
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2
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1
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2
-
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-
748094
Glenn
Allosteric regulation of Lact ...
Lactobacillus plantarum
J. Bacteriol.
197
1157-1163
2015
-
-
1
-
-
-
4
1
-
-
-
2
-
4
-
-
1
-
-
-
-
-
2
-
-
-
-
2
1
-
-
1
-
-
3
-
-
1
1
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-
-
3
4
-
1
-
-
-
2
-
-
-
1
-
-
-
-
2
-
-
-
-
2
1
-
-
-
-
-
-
-
2
2
748512
Taylor
Biolistic transformation of a ...
Cryptococcus neoformans
J. Vis. Exp.
97
e52666
2015
-
-
-
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-
-
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1
-
4
-
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3
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1
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1
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3
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1
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-
-
-
748753
Xiong
Phosphoketolase pathway contr ...
Synechocystis sp. DELTAglgC/xylAB
Nat. Plants
2
15187
2015
-
-
-
-
-
-
-
-
-
-
-
1
-
1
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1
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1
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1
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-
-
727394
Glenn
Biochemical and kinetic charac ...
Cryptococcus neoformans
Eukaryot. Cell
13
657-663
2014
1
-
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-
3
-
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4
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1
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1
1
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1
3
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1
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-
746881
Petrareanu
Phosphoketolases from Lactoco ...
Lactococcus lactis, Lactococcus lactis subsp. lactis, Lactococcus lactis subsp. lactis IL1403, Leuconostoc mesenteroides, Leuconostoc mesenteroides subsp. mesenteroides, Leuconostoc mesenteroides subsp. mesenteroides J18, Pseudomonas aeruginosa
Appl. Microbiol. Biotechnol.
98
7855-7867
2014
-
-
5
-
-
-
-
10
-
-
-
6
-
8
-
-
5
-
-
-
-
-
16
3
3
3
-
12
3
-
-
5
-
1
-
-
-
6
6
-
-
-
-
-
-
12
-
-
-
6
-
-
-
6
-
-
-
-
16
3
3
3
-
12
3
-
-
1
-
-
-
-
10
12
747246
Tittmann
Sweet siblings with different ...
Bifidobacterium breve
Bioorg. Chem.
57
263-280
2014
-
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2
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1
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2
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1
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1
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2
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-
2
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-
-
-
728652
Bolado-Martinez
Fructose 6-phosphate phosphoke ...
Lactobacillus sp.
Prikl. Biokhim. Mikrobiol.
48
494-500
2012
-
-
-
-
-
-
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8
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1
1
-
-
-
713918
Fleige
Establishment of an alternativ ...
Cupriavidus necator
Appl. Microbiol. Biotechnol.
91
769-776
2011
-
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1
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1
-
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4
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2
1
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1
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1
1
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1
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2
1
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704232
Cleusix
Comparative study of a new qua ...
Bifidobacterium animalis subsp. lactis, Bifidobacterium longum
J. Appl. Microbiol.
108
181-193
2010
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2
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5
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2
-
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713652
Suzuki
Overexpression, crystallizatio ...
Bifidobacterium breve 203, Bifidobacterium breve
Acta Crystallogr. Sect. F
66
941-943
2010
-
-
1
1
-
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2
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1
5
-
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6
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1
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4
1
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2
1
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1
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1
1
1
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2
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1
5
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1
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4
1
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2
1
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715026
Takahashi
Crystal structure of Bifidobac ...
Bifidobacterium longum, Bifidobacterium longum JCM 1217
FEBS Lett.
584
3855-3861
2010
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-
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1
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1
1
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6
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1
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4
1
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1
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1
1
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1
1
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1
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4
1
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715551
Suzuki
Crystal structures of phosphok ...
Bifidobacterium breve
J. Biol. Chem.
285
34279-34287
2010
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1
1
17
-
-
14
-
1
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2
-
3
-
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-
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2
1
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7
-
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1
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1
1
1
17
-
-
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-
14
-
1
-
2
-
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-
-
-
-
-
-
2
1
-
-
-
7
-
-
-
-
-
-
-
-
-
-
701819
Martin
Isolation of bifidobacteria fr ...
Bifidobacterium adolescentis, Bifidobacterium bifidum, Bifidobacterium breve, Bifidobacterium dentium, Bifidobacterium longum
Appl. Environ. Microbiol.
75
965-969
2009
-
-
-
-
-
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10
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5
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5
-
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-
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-
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-
701841
Roopashri
Molecular characterization of ...
Bifidobacterium adolescentis, Bifidobacterium adolescentis MTCC 5423
Appl. Microbiol. Biotechnol.
83
1115-1126
2009
-
-
-
-
-
-
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2
-
10
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2
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2
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2
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704102
Watanabe
Bifidobacterium mongoliense sp ...
Bifidobacterium mongoliense
Int. J. Syst. Evol. Microbiol.
59
1535-1540
2009
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704103
Killer
Bifidobacterium bombi sp. nov. ...
Bifidobacterium bombi, Bifidobacterium bombi BluCI/TP / DSM 19703 / ATCC BAA-1567
Int. J. Syst. Evol. Microbiol.
59
2020-2024
2009
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681361
Jeong
Cloning and characterization o ...
Lactobacillus paraplantarum, Lactobacillus paraplantarum C7
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822-829
2007
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664428
Lee
Cloning and characterization o ...
Leuconostoc mesenteroides, Leuconostoc mesenteroides C7
Biotechnol. Lett.
27
853-858
2005
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664992
Yin
The gene encoding xylulose-5-p ...
Bifidobacterium sp.
FEMS Microbiol. Lett.
246
251-257
2005
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664983
Sanchez
Acquired resistance to bile in ...
Bifidobacterium sp.
FEMS Microbiol. Lett.
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35-41
2004
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651682
Meile
Characterization of the D-xylu ...
Bifidobacterium animalis subsp. lactis
J. Bacteriol.
183
2929-2936
2001
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1
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653088
Fandi
Purification and N-terminal am ...
Bifidobacterium longum, Bifidobacterium longum BB536
Lett. Appl. Microbiol.
32
235-239
2001
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5098
Gavini
-
Detection of fructose-6-phosph ...
Bifidobacterium bifidum, Bifidobacterium sp., Gardnerella vaginalis, no activity in Actinomyces turicensis-like bacteria
Anaerobe
2
191-193
1996
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4
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5097
Whitworth
-
Phosphoketolase in Rhodotorula ...
Candida sp. (in: Saccharomycetales), Candida sp. (in: Saccharomycetales) 107, Candida tropicalis, Rhodotorula glutinis, Rhodotorula graminis, Saccharomyces pastorianus
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1977
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6
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5096
Sgorbath
Purification and properties of ...
Bifidobacterium dentium, Bifidobacterium pseudolongum subsp. globosum
Antonie van Leeuwenhoek
42
49-57
1976
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8
2
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2
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8
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11
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6
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8
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2
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11
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6
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2
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5095
Schramm
Phosphorolytic cleavage of fru ...
Komagataeibacter xylinus
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233
1283-1288
1958
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