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Literature summary for 4.1.2.13 extracted from

  • Ziveri, J.; Tros, F.; Guerrera, I.C.; Chhuon, C.; Audry, M.; Dupuis, M.; Barel, M.; Korniotis, S.; Fillatreau, S.; Gales, L.; Cahoreau, E.; Charbit, A.
    The metabolic enzyme fructose-1,6-bisphosphate aldolase acts as a transcriptional regulator in pathogenic Francisella (2017), Nat. Commun., 8, 853 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.1.2.13

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-fructose 1,6-bisphosphate Francisella tularensis subsp. novicida
-
 glycerone phosphate + D-glyceraldehyde 3-phosphate
-
 r
D-fructose 1,6-bisphosphate Francisella tularensis subsp. novicida U112
-
 glycerone phosphate + D-glyceraldehyde 3-phosphate
-
 r

Organism

Organism UniProt Comment Textmining
Francisella tularensis subsp. novicida
-
-
-
Francisella tularensis subsp. novicida A0Q7I9
-
-
Francisella tularensis subsp. novicida U112
-
-
-
Francisella tularensis subsp. novicida U112 A0Q7I9
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-fructose 1,6-bisphosphate
-
 Francisella tularensis subsp. novicida glycerone phosphate + D-glyceraldehyde 3-phosphate
-
 r
D-fructose 1,6-bisphosphate
-
 Francisella tularensis subsp. novicida U112 glycerone phosphate + D-glyceraldehyde 3-phosphate
-
 r

Synonyms

Synonyms Comment Organism
FBA
-
 Francisella tularensis subsp. novicida
fructose-1,6-bisphosphate aldolase
-
 Francisella tularensis subsp. novicida
fructose-bisphosphate aldolase
-
 Francisella tularensis subsp. novicida

General Information

General Information Comment Organism
drug target potential target for drug development against pathogenic bacteria Francisella tularensis subsp. novicida
malfunction enzyme inactivation impairs virulence and increases resistance to oxidative stress Francisella tularensis subsp. novicida
physiological function the enzyme is important for bacterial multiplication in macrophages in the presence of gluconeogenic substrates. In addition, there is a direct role of this metabolic enzyme in transcription regulation of genes katG and rpoA, encoding catalase and an RNA polymerase subunit, respectively Francisella tularensis subsp. novicida
physiological function the enzyme occupies a central position in glycolysis and gluconeogenesis pathways. Fructose-bisphosphate aldolase is important for bacterial multiplication in macrophages in the presence of gluconeogenic substrates. Direct role of this metabolic enzyme in transcription regulation of genes katG and rpoA, encoding catalase and an RNA polymerase subunit, respectively Francisella tularensis subsp. novicida