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Literature summary for 4.1.2.13 extracted from

  • Szwergold, B.S.; Ugurbil, K.; Brown, T.R.
    Properties of fructose-1,6-bisphosphate aldolase from Escherichia coli: an NMR analysis (1995), Arch. Biochem. Biophys., 317, 244-252.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
3-phosphoglycerate
-
 Escherichia coli
diphosphate
-
 Escherichia coli
EDTA
-
 Escherichia coli
glyceraldehyde 3-phosphate
-
 Escherichia coli
glycerone phosphate
-
 Escherichia coli
Polyphosphate
-
 Escherichia coli

Metals/Ions

Metals/Ions Comment Organism Structure
Cd2+ can partially restore activity of metal depleted enzyme Escherichia coli
Mn2+ can partially restore activity of metal depleted enzyme Escherichia coli
Zn2+ the function appears to be the polarization of the C=O bound of glycerone phosphate. Each subunit of the dimer binds one Zn2+ Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Escherichia coli

Reaction

Reaction Comment Organism Reaction ID
D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate the enzyme binds and utilizes only the carbonyl forms of fructose 1,6-diphosphate and glycerone phosphate Escherichia coli
a

Storage Stability

Storage Stability Organism
-10°C, stable for up to 12 months Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-fructose 1,6-bisphosphate
-
 Escherichia coli glycerone phosphate + D-glyceraldehyde 3-phosphate
-
 ?
D-Fructose 1-phosphate at 3.5% of the activity with fructose 1,6-diphosphate Escherichia coli Glycerone phosphate + D-glyceraldehyde
-
 ?

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
25
-
 3 d, 25% loss of activity Escherichia coli