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Literature summary for 4.1.1.94 extracted from

  • Asai, S.; Miura, N.; Sawada, Y.; Noda, T.; Kikugawa, T.; Tanji, N.; Saika, T.
    Silencing of ECHDC1 inhibits growth of gemcitabine-resistant bladder cancer cells (2018), Oncol. Lett., 15, 522-527 .
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine ECHDC1 expression is increased in gemcitabine-resistant bladder cancer cells, and is involved in their cell growth. Silencing of ECHDC1 significantly inhibits the proliferation of a gemcitabine-resistant UMUC-3-derived cell line. Silencing of ECHDC1 induces upregulation of p27, which is critical for cell cycle arrest in the G1 phase, and induces G1 arrest Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9NTX5
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Source Tissue

Source Tissue Comment Organism Textmining
HT-1376 cell
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 Homo sapiens
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UM-UC-3 cell
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 Homo sapiens
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General Information

General Information Comment Organism
physiological function ECHDC1 expression is increased in gemcitabine-resistant bladder cancer cells, and is involved in their cell growth. Silencing of ECHDC1 significantly inhibits the proliferation of a gemcitabine-resistant UMUC-3-derived cell line. Silencing of ECHDC1 induces upregulation of p27, which is critical for cell cycle arrest in the G1 phase, and induces G1 arrest Homo sapiens