Literature summary for 4.1.1.9 extracted from

Campbell, F.M.; Kozak, R.; Wagner, A.; Altarejos, J.Y.; Dyck, J.R.B.; Belke, D.D.; Severson, D.L.; Kelly, D.P.; Lopaschuk, G.D.
A role for peroxisome proliferator-activated receptor alpha (PPARalpha) in the control of cardiac malonyl-CoA levels. Reduced fatty acid oxidation rates and increased glucose oxidation rates in the hearts of mice lacking PPARalpha are associated with higher concentrations of malonyl-CoA and reduced expression of malonyl-CoA decarboxylase (2002), J. Biol. Chem., 277, 4098-4103.

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
Malonyl-CoA	Mus musculus	malonyl-CoA degradation, transcriptional control of MCD by peroxisome proliferator-activated receptor alpha, involved in the regulation of fatty acid oxidation	Acetyl-CoA + CO2	-	?

Organism	UniProt	Comment	Textmining
Mus musculus	-	mice lacking peroxisome proliferator-activated receptor alpha and age-matched wild-type Sv/129 mice	-

Source Tissue	Comment	Organism	Textmining

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Malonyl-CoA	-	Mus musculus	Acetyl-CoA + CO2	-	?
Malonyl-CoA	malonyl-CoA degradation, transcriptional control of MCD by peroxisome proliferator-activated receptor alpha, involved in the regulation of fatty acid oxidation	Mus musculus	Acetyl-CoA + CO2	-	?

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Release 2023.1 (January 2023)