Literature summary for 4.1.1.84 extracted from

Ji, H.; Zhang, Y.; Chen, C.; Li, H.; He, B.; Yang, T.; Sun, C.; Hao, H.; Zhang, X.; Wang, Y.; Zhou, Y.; Zhu, Z.; Hu, Y.; Li, A.; Guo, A.; Wang, Y.
D-dopachrome tautomerase activates COX2/PGE2 pathway of astrocytes to mediate inflammation following spinal cord injury (2021), J. Neuroinflammation, 18, 130.

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Inhibitors

Inhibitors	Comment	Organism	Structure
4-(3-carboxyphenyl)-2,5-pyridinedicarboxylic acid	specifically inhibits DDT-induced PGE2 production in astrocytes	Rattus norvegicus
4-iodo-6-phenylpyrimidine	inhibition of DDT is efficient in attenuating DDT-induced astrocyte production of PGE2 following spinal cord injury	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	P80254	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
astrocyte	DDT is inducibly expressed within astrocytes and neurons, rather than in microglia following spinal cord contusion	Rattus norvegicus	-
neuron	DDT is inducibly expressed within astrocytes and neurons, rather than in microglia following spinal cord contusion	Rattus norvegicus	-
spinal cord	DDT is inducibly expressed within astrocytes and neurons, rather than in microglia following spinal cord contusion	Rattus norvegicus	-

Synonyms

Synonyms	Comment	Organism
DDT	-	Rattus norvegicus

General Information

General Information	Comment	Organism
physiological function	recombinant DDT is able to activate the COX2/PGE2 signal pathway of astrocytes through CD74 receptor, the intracellular activation of mitogen-activated protein kinases is involved in the regulation of DDT action. Inhibition of DDT promotes the recovery of motor function following spinal cord injury	Rattus norvegicus

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Release 2026.1 (March 2026)