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Literature summary for 4.1.1.84 extracted from
- Overexpression of D-dopachrome tautomerase increases ultraviolet B irradiation-induced skin tumorigenesis in mice (2021), FASEB J., 35, e21671.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | DDT is associated with UVB-induced skin tumorigenesis. DDT overexpression exerts p53-antagonizing effects and inhibits the apoptosis signaling pathway | Mus musculus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | O35215 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| keratinocyte | - |
Mus musculus | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| DDT | - |
Mus musculus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | chronic UVB exposure accelerates tumor development in DDT overexpressing mice, with a higher incidence of tumors observed in DDT overexpressing mice than in wild-type mice. In DDT overexpressing irradiated mouse keratinocytes, the p53, PUMA, and Bax expression is lower than that in wild-type | Mus musculus |
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