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Literature summary for 4.1.1.84 extracted from

  • Song, S.; Liu, B.; Habibie, H.; van den Bor, J.; Smit, M.J.; Gosens, R.; Wu, X.; Brandsma, C.A.; Cool, R.H.; Haisma, H.J.; Poelarends, G.J.; Melgert, B.N.
    D-dopachrome tautomerase contributes to lung epithelial repair via atypical chemokine receptor 3-dependent Akt signaling (2021), EBioMedicine, 68, 103412.
    View publication on PubMed
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Application

Application Comment Organism
medicine DDT promotes A-549 epithelial cell proliferation and protects them from apoptosis. DDT mediates its anti-apoptotic effects through ACKR3 in A-549 epithelial cells Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P30046
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-

Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell
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 Homo sapiens
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lung DDT is expressed by ATII cells in lung tissue Homo sapiens
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Synonyms

Synonyms Comment Organism
DDT
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function DDT promotes proliferation of and prevents staurosporine-induced apoptosis in A-549 lung epithelial cells. DDT also stimulates growth of primary alveolar epithelial cells. DDT treatment results in significantly more and larger murine and human alveolar organoids compared to untreated controls. The anti-apoptotic effect of DDT and DDT-induced organoid growth are inhibited in the presence of an ACKR3-blocking nanobody. DDT complexes with ACKR3. DDT can activate the PI3K-Akt pathway which is enhanced in ACKR3-overexpressing cells Homo sapiens