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Literature summary for 4.1.1.84 extracted from

  • Li, H.; He, B.; Zhang, X.; Hao, H.; Yang, T.; Sun, C.; Song, H.; Wang, Y.; Zhou, Y.; Zhu, Z.; Hu, Y.; Wang, Y.
    D-dopachrome tautomerase drives astroglial inflammation via NF-kappaB signaling following spinal cord injury (2022), Cell Biosci., 12, 128.
    View publication on PubMed
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Organism

Organism UniProt Comment Textmining
Rattus norvegicus P80254
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Source Tissue

Source Tissue Comment Organism Textmining
astrocyte
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 Rattus norvegicus
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neuron
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 Rattus norvegicus
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spinal cord
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 Rattus norvegicus
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General Information

General Information Comment Organism
physiological function DDT protein levels are significantly elevated within neurons and astrocytes following spinal cord injury. Recombinant DDT is efficient in inducing the production of inflammatory cytokines from astrocytes through interaction with CD74 receptor. Activation of mitogen-activated protein kinases and NF-kappaB is essential for the transduction of DDT signaling Rattus norvegicus