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Literature summary for 4.1.1.84 extracted from

  • Nishihira, J.; Fujinaga, M.; Kuriyama, T.; Suzuki, M.; Sugimoto, H.; Nakagawa, A.; Tanaka, I.; Sakai, M.
    Molecular cloning of human D-dopachrome tautomerase cDNA: N-terminal proline is essential for enzyme activation (1998), Biochem. Biophys. Res. Commun., 243, 538-544.
    View publication on PubMed
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Cloned(Commentary)

Cloned (Comment) Organism
cDNA of 566 base pairs, expressed in Escherichia coli Homo sapiens

Protein Variants

Protein Variants Comment Organism
P1A enzyme activity extremely decreased Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.42
-
 D-dopachrome 25°C, pH 6.5, wild type enzyme Homo sapiens
0.44
-
 D-dopachrome 25°C, pH 6.5, P1A mutant Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
13000
-
 x * 13000, SDS-PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P30046
-
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
100
-
 25°C, pH 6.5, wild type enzyme Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-dopachrome
-
 Homo sapiens 5,6-dihydroxyindole + CO2
-
 ?

Subunits

Subunits Comment Organism
? x * 13000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
D-dopachrome tautomerase
-
 Homo sapiens