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Literature summary for 4.1.1.80 extracted from
- Distant precursors of benzylisoquinoline alkaloids and their enzymatic formation (1987), Z. Naturforsch. C, 42, 319-332.
No PubMed abstract available
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.67 | - |
4-hydroxyphenylpyruvate | - |
Berberis stolonifera |  |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 30000 | - |
HPLC gel filtration | Berberis stolonifera |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4-hydroxyphenylpyruvate | Berberis stolonifera | involved in tyrosine metabolism, precursor of tyrosine, early steps of isoquinoline alkaloid biosynthesis | 4-hydroxyphenylacetaldehyde + CO2 | phenylacetaldehydes furnish the benzylic moiety of the isoquinoline alkaloids in their biosynthesis, formation of the 1-benzylisoquinoline structure requires the condensation of p-hydroxyphenylacetaldehyde with dopamine to form norcoclaurine | ? | |
| 4-hydroxyphenylpyruvate | Berberis canadensis | involved in tyrosine metabolism, precursor of tyrosine, early steps of isoquinoline alkaloid biosynthesis | 4-hydroxyphenylacetaldehyde + CO2 | phenylacetaldehydes furnish the benzylic moiety of the isoquinoline alkaloids in their biosynthesis, formation of the 1-benzylisoquinoline structure requires the condensation of p-hydroxyphenylacetaldehyde with dopamine to form norcoclaurine | ? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Berberis aristata | - |
- |
- |
| Berberis canadensis | - |
produces large amounts of protoberberine alkaloids of the jatrorrhizine type | - |
| Berberis julianae | - |
- |
- |
| Berberis regeliana | - |
- |
- |
| Berberis stolonifera | - |
- |
- |
| Eschscholzia californica | - |
- |
- |
| Hyalosepalum caffrum | - |
- |
- |
| Thalictrum dipterocarpum | - |
- |
- |
| Thalictrum minus | - |
- |
- |
| Tinospora cordifolia | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| 29fold partial purification | Berberis stolonifera |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| callus | - |
Berberis canadensis | - |
| cell suspension culture | - |
Eschscholzia californica | - |
| cell suspension culture | - |
Berberis regeliana | - |
| cell suspension culture | - |
Thalictrum minus | - |
| cell suspension culture | - |
Berberis stolonifera | - |
| cell suspension culture | - |
Berberis julianae | - |
| cell suspension culture | - |
Thalictrum dipterocarpum | - |
| cell suspension culture | - |
Hyalosepalum caffrum | - |
| cell suspension culture | - |
Tinospora cordifolia | - |
| cell suspension culture | - |
Berberis aristata | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
values given as pkat/litre of suspension culture | Eschscholzia californica |
| additional information | - |
values given as pkat/litre of suspension culture | Berberis regeliana |
| additional information | - |
values given as pkat/litre of suspension culture | Thalictrum minus |
| additional information | - |
values given as pkat/litre of suspension culture | Berberis julianae |
| additional information | - |
values given as pkat/litre of suspension culture | Thalictrum dipterocarpum |
| additional information | - |
values given as pkat/litre of suspension culture | Hyalosepalum caffrum |
| additional information | - |
values given as pkat/litre of suspension culture | Tinospora cordifolia |
| additional information | - |
values given as pkat/litre of suspension culture | Berberis aristata |
| 0.001271 | - |
- |
Berberis stolonifera |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4-hydroxyphenylpyruvate | - |
Berberis stolonifera | 4-hydroxyphenylacetaldehyde + CO2 | - |
? | |
| 4-hydroxyphenylpyruvate | - |
Berberis canadensis | 4-hydroxyphenylacetaldehyde + CO2 | - |
? | |
| 4-hydroxyphenylpyruvate | involved in tyrosine metabolism, precursor of tyrosine, early steps of isoquinoline alkaloid biosynthesis | Berberis stolonifera | 4-hydroxyphenylacetaldehyde + CO2 | phenylacetaldehydes furnish the benzylic moiety of the isoquinoline alkaloids in their biosynthesis, formation of the 1-benzylisoquinoline structure requires the condensation of p-hydroxyphenylacetaldehyde with dopamine to form norcoclaurine | ? | |
| 4-hydroxyphenylpyruvate | involved in tyrosine metabolism, precursor of tyrosine, early steps of isoquinoline alkaloid biosynthesis | Berberis canadensis | 4-hydroxyphenylacetaldehyde + CO2 | phenylacetaldehydes furnish the benzylic moiety of the isoquinoline alkaloids in their biosynthesis, formation of the 1-benzylisoquinoline structure requires the condensation of p-hydroxyphenylacetaldehyde with dopamine to form norcoclaurine | ? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
assay at | Berberis stolonifera |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.5 | - |
- |
Berberis stolonifera |
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Release 2023.1 (January 2023)
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