Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Oxalyl-CoA | Escherichia coli | - |
Formyl-CoA + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
strains K-12 BW25113 and MG1655, gene yfdU | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Oxalyl-CoA | - |
Escherichia coli | Formyl-CoA + CO2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
yfdU | - |
Escherichia coli |
General Information | Comment | Organism |
---|---|---|
malfunction | the absence of the YfdU protein increases the cell vulnerability to low pH, oxalic acid, or both. Oxalate-dependent pH tolerance of the yfdU-deletion strain is clearly impaired, glutamate-dependent acid resistance is not impaired by deletion of the either yfdW or yfdU | Escherichia coli |
physiological function | the enzymes YfdW, a formyl coenzyme A (CoA) transferase, and YfdU, an oxalyl-CoA decarboxylase, are required for oxalate adaptation but not during challenge in minimal challenge medium. YfdW and YfdU are part of an AR2-like system where oxalate is brought into the cell by YhjX and decarboxylated in a reaction similar to that catalyzed by GadA/B in the challenge medium. Oxalate induces an acid tolerance response when Escherichia coli cells are adapted at pH 5.5 and the enzymes YfdW and YfdU, but not YhjX, are required for this response, overview | Escherichia coli |