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Literature summary for 4.1.1.76 extracted from

  • Gassmeyer, S.; Wetzig, J.; Mügge, C.; Assmann, M.; Enoki, J.; Hilterhaus, L.; Zuhse, R.; Miyamoto, K.; Liese, A.; Kourist, R.
    Arylmalonate decarboxylase-catalyzed asymmetric synthesis of both enantiomers of optically pure flurbiprofen (2016), ChemCatChem, 8, 916-921 .
No PubMed abstract available
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Protein Variants

Protein Variants Comment Organism
G74C/M159L/C188G/P14V/P15G inactive Bordetella bronchiseptica
G74C/M159L/C188G/V43I/A125P/V156l contrary to wild-type, mutant synthesizes the (S)-enantiomer of 2-methyl-2-(2-fluoro-4-biphenyl)propionate Bordetella bronchiseptica

Organism

Organism UniProt Comment Textmining
Bordetella bronchiseptica Q05115
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-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-(2-fluoro-4-biphenyl)-2-methylmalonate
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 Bordetella bronchiseptica (R)-2-methyl-2-(2-fluoro-4-biphenyl)propionate + CO2
-
 ?
2-(2-fluoro-4-biphenyl)-2-methylmalonate
-
 Bordetella bronchiseptica (S)-2-methyl-2-(2-fluoro-4-biphenyl)propionate + CO2
-
 ?