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Literature summary for 4.1.1.76 extracted from

  • Okrasa, K.; Levy, C.; Hauer, B.; Baudendistel, N.; Leys, D.; Micklefield, J.
    Structure and mechanism of an unusual malonate decarboxylase and related racemases (2008), Chem. Eur. J., 14, 6609-6613.
    View publication on PubMed
Search for more literature for 4.1.1.76

Cloned(Commentary)

Cloned (Comment) Organism
cloned and overexpressed in Escherichia coli Bordetella bronchiseptica

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
9.6
-
 Phenylmalonate
-
 Chelativorans sp. BNC1
10
-
 Phenylmalonate
-
 Bordetella bronchiseptica
10.7
-
 Phenylmalonate
-
 Bordetella bronchiseptica
22.2
-
 2-methyl-2-phenylmalonate
-
 Chelativorans sp. BNC1
26.9
-
 2-methyl-2-phenylmalonate
-
 Bordetella bronchiseptica
41.7
-
 Phenylmalonate
-
 Pyrococcus horikoshii
123
-
 Phenylmalonate
-
 Alkaliphilus metalliredigens QYMF

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2-aryl-2-methylmalonate Chelativorans sp. BNC1
-
 2-arylpropionate + CO2
-
 ?
2-aryl-2-methylmalonate Bordetella bronchiseptica
-
 2-arylpropionate + CO2
-
 ?
2-aryl-2-methylmalonate Alkaliphilus metalliredigens QYMF
-
 2-arylpropionate + CO2
-
 ?
2-aryl-2-methylmalonate Pyrococcus horikoshii
-
 2-arylpropionate + CO2
-
 ?
2-aryl-2-methylmalonate Bordetella bronchiseptica RB50
-
 2-arylpropionate + CO2
-
 ?
2-aryl-2-methylmalonate Pyrococcus horikoshii OT-3
-
 2-arylpropionate + CO2
-
 ?
alpha-aryl-alpha-methylmalonate Bordetella bronchiseptica
-
 alpha-arylpropionate + CO2
-
 ?
alpha-aryl-alpha-methylmalonate Bordetella bronchiseptica KU1201
-
 alpha-arylpropionate + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Alkaliphilus metalliredigens QYMF
-
-
-
Bordetella bronchiseptica A0A0H3LJU9 RB50
-
Bordetella bronchiseptica Q05115 KU1201
-
Bordetella bronchiseptica KU1201 Q05115 KU1201
-
Bordetella bronchiseptica RB50 A0A0H3LJU9 RB50
-
Chelativorans sp. BNC1
-
-
-
Pyrococcus horikoshii O58713 OT3
-
Pyrococcus horikoshii OT-3 O58713 OT3
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2(thien-2-yl) malonate
-
 Bordetella bronchiseptica ? + CO2
-
 ?
2-aryl-2-methylmalonate
-
 Bordetella bronchiseptica 2-arylpropionate + CO2
-
 ?
2-aryl-2-methylmalonate
-
 Chelativorans sp. BNC1 2-arylpropionate + CO2
-
 ?
2-aryl-2-methylmalonate
-
 Alkaliphilus metalliredigens QYMF 2-arylpropionate + CO2
-
 ?
2-aryl-2-methylmalonate
-
 Pyrococcus horikoshii 2-arylpropionate + CO2
-
 ?
2-aryl-2-methylmalonate
-
 Bordetella bronchiseptica KU1201 2-arylpropionate + CO2
-
 ?
2-aryl-2-methylmalonate
-
 Bordetella bronchiseptica RB50 2-arylpropionate + CO2
-
 ?
2-aryl-2-methylmalonate
-
 Pyrococcus horikoshii OT-3 2-arylpropionate + CO2
-
 ?
2-methyl-2-(naphthalen-2-yl)malonate
-
 Bordetella bronchiseptica 2-(naphthalen-2-yl)propionate + CO2
-
 ?
2-methyl-2-(thien-2-yl)malonate
-
 Bordetella bronchiseptica 2-(thien-2-yl)propionate + CO2
-
 ?
2-methyl-2-phenylmalonate
-
 Bordetella bronchiseptica 2-phenylpropanoate + CO2
-
 ?
2-methyl-2-phenylmalonate
-
 Bordetella bronchiseptica KU1201 2-phenylpropanoate + CO2
-
 ?
2-methyl-2-phenylpropionate
-
 Chelativorans sp. BNC1 ? + CO2
-
 ?
2-phenyl-2-methylmalonate
-
 Bordetella bronchiseptica (2R)-phenylpropionate + CO2
-
 ?
2-phenyl-2-methylmalonate
-
 Bordetella bronchiseptica KU1201 (2R)-phenylpropionate + CO2
-
 ?
alpha-aryl-alpha-methylmalonate
-
 Bordetella bronchiseptica alpha-arylpropionate + CO2
-
 ?
alpha-aryl-alpha-methylmalonate
-
 Bordetella bronchiseptica KU1201 alpha-arylpropionate + CO2
-
 ?
Phenylmalonate
-
 Bordetella bronchiseptica Phenylacetate + CO2
-
 ?
Phenylmalonate
-
 Chelativorans sp. BNC1 Phenylacetate + CO2
-
 ?
Phenylmalonate
-
 Alkaliphilus metalliredigens QYMF Phenylacetate + CO2
-
 ?
Phenylmalonate
-
 Pyrococcus horikoshii Phenylacetate + CO2
-
 ?
Phenylmalonate
-
 Bordetella bronchiseptica KU1201 Phenylacetate + CO2
-
 ?
Phenylmalonate
-
 Bordetella bronchiseptica RB50 Phenylacetate + CO2
-
 ?
Phenylmalonate
-
 Pyrococcus horikoshii OT-3 Phenylacetate + CO2
-
 ?

Synonyms

Synonyms Comment Organism
AMDase
-
 Bordetella bronchiseptica
AMDase
-
 Chelativorans sp. BNC1
AMDase
-
 Alkaliphilus metalliredigens QYMF
AMDase
-
 Pyrococcus horikoshii
Arylmalonate decarboxylase
-
 Bordetella bronchiseptica
Arylmalonate decarboxylase
-
 Chelativorans sp. BNC1
Arylmalonate decarboxylase
-
 Alkaliphilus metalliredigens QYMF
Arylmalonate decarboxylase
-
 Pyrococcus horikoshii

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.09
-
 Phenylmalonate
-
 Pyrococcus horikoshii
0.26
-
 Phenylmalonate
-
 Alkaliphilus metalliredigens QYMF
12.4
-
 Phenylmalonate
-
 Bordetella bronchiseptica
55.8
-
 2-methyl-2-phenylmalonate
-
 Chelativorans sp. BNC1
118
-
 Phenylmalonate
-
 Chelativorans sp. BNC1
279
-
 2-methyl-2-phenylmalonate
-
 Bordetella bronchiseptica
316
-
 Phenylmalonate
-
 Bordetella bronchiseptica