Literature summary for 4.1.1.65 extracted from

Thanawastien, A.; Montor, W.R.; Labaer, J.; Mekalanos, J.J.; Yoon, S.S.
Vibrio cholerae proteome-wide screen for immunostimulatory proteins identifies phosphatidylserine decarboxylase as a novel Toll-like receptor 4 agonist (2009), PLoS Pathog., 5, e1000556.

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Organism

Organism	UniProt	Comment	Textmining
Vibrio cholerae serotype O1	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Phosphatidyl-L-serine	-	Vibrio cholerae serotype O1	Phosphatidylethanolamine + CO2	-	?

Synonyms

Synonyms	Comment	Organism
PSD	-	Vibrio cholerae serotype O1

General Information

General Information	Comment	Organism
physiological function	phosphatidylserine decarboxylase is a Toll-like receptor 4 agonist, phosphatidylserine decarboxylase in concentrations as low as 100 ng/ml stimulates RAW264.7 murine macrophage cells and primary peritoneal macrophage cells to secrete tissue necrosis factor alpha and interleukin-6, respectively. PSD induces the production of interleukin-6, in part, via its enzymatic activity	Vibrio cholerae serotype O1

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Release 2023.1 (January 2023)