BRENDA - Enzyme Database
show all sequences of 4.1.1.53

On the importance of decarboxylation in the metabolism of phenylalanine, tyrosine, and tryptophan

David, J.C.; Dairman, W.; Udenfriend, S.; Arch. Biochem. Biophys. 160, 561-568 (1974)

Data extracted from this reference:

Application
Application
Commentary
Organism
pharmacology
side-effects of pharmacologically active decarboxylation products considered
Homo sapiens
Inhibitors
Inhibitors
Commentary
Organism
Structure
5-Aminooxymethyl-2-bromophenol
brocresine, 75 mg/kg body mass cause 98% inhibition of liver enzyme in vivo
Rattus norvegicus
N1-(DL-Seryl)-N2-(2,3,4)-trihydroxybenzyl hydrazine
50 mg/kg cause 99% inhibition of liver enzyme in vivo
Rattus norvegicus
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
Phenylalanine
Rattus norvegicus
-
?
-
-
-
Tryptophan
Rattus norvegicus
-
?
-
-
-
Tyrosine
Rattus norvegicus
-
?
-
-
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
-
human
-
Rattus norvegicus
-
rat
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
brain
-
Rattus norvegicus
-
kidney
-
Rattus norvegicus
-
liver
-
Rattus norvegicus
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Phenylalanine
-
4705
Rattus norvegicus
?
-
-
-
-
Tryptophan
-
4705
Rattus norvegicus
?
-
-
-
-
Tyrosine
-
4705
Rattus norvegicus
?
-
-
-
-
Cofactor
Cofactor
Commentary
Organism
Structure
pyridoxal 5'-phosphate
-
Homo sapiens
pyridoxal 5'-phosphate
-
Rattus norvegicus
Application (protein specific)
Application
Commentary
Organism
pharmacology
side-effects of pharmacologically active decarboxylation products considered
Homo sapiens
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
pyridoxal 5'-phosphate
-
Homo sapiens
pyridoxal 5'-phosphate
-
Rattus norvegicus
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
5-Aminooxymethyl-2-bromophenol
brocresine, 75 mg/kg body mass cause 98% inhibition of liver enzyme in vivo
Rattus norvegicus
N1-(DL-Seryl)-N2-(2,3,4)-trihydroxybenzyl hydrazine
50 mg/kg cause 99% inhibition of liver enzyme in vivo
Rattus norvegicus
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
Phenylalanine
Rattus norvegicus
-
?
-
-
-
Tryptophan
Rattus norvegicus
-
?
-
-
-
Tyrosine
Rattus norvegicus
-
?
-
-
-
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
brain
-
Rattus norvegicus
-
kidney
-
Rattus norvegicus
-
liver
-
Rattus norvegicus
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Phenylalanine
-
4705
Rattus norvegicus
?
-
-
-
-
Tryptophan
-
4705
Rattus norvegicus
?
-
-
-
-
Tyrosine
-
4705
Rattus norvegicus
?
-
-
-
-
Other publictions for EC 4.1.1.53
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
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Sytykiewicz
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728786
Stevenson
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Proteus mirabilis
Res. Microbiol.
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1
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679891
Marcobal
First genetic characterization ...
Enterococcus faecium
FEMS Microbiol. Lett.
258
144-149
2006
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1
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654188
Ziadeh
Enzymatic decarboxylation of t ...
Enterococcus faecalis
Anal. Chem.
74
479-483
2002
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4707
Buckberry
-
Cysteine conjugate beta-lyase ...
Enterococcus faecalis
Biochem. Soc. Trans.
26
269
1998
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1
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1
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4231
Jebai
Expression, purification, and ...
Rattus norvegicus
Protein Expr. Purif.
11
185-194
1997
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1
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2
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1
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4709
Taylor
-
Metabolism of D,L-chlorophenyl ...
no activity in Papaver somniferum, Phaseolus vulgaris
Biochemistry
26
1279-1288
1987
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4706
Chen
A rapid procedure for detectio ...
Morganella morganii
Anal. Biochem.
111
60-66
1981
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4708
Nakazawa
-
Distribution and formation of ...
Achromobacter sp., Micrococcus percitreus, Micrococcus sp., Sarcina sp., Staphylococcus sp.
Agric. Biol. Chem.
41
2241-2247
1977
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5
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21
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21
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5
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5
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4705
David
On the importance of decarboxy ...
Homo sapiens, Rattus norvegicus
Arch. Biochem. Biophys.
160
561-568
1974
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2
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4704
Lovenberg
Aromatic L-amino acid decarbox ...
Canis lupus, Cavia aperea
J. Biol. Chem.
237
89-93
1962
1
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6
6
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1
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2
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2
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6
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1
13
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1
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1
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2
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1
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2
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6
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6
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1
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6
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1
13
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1
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1
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