Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 4.1.1.53 extracted from

  • David, J.C.; Dairman, W.; Udenfriend, S.
    On the importance of decarboxylation in the metabolism of phenylalanine, tyrosine, and tryptophan (1974), Arch. Biochem. Biophys., 160, 561-568.
    View publication on PubMed
Search for more literature for 4.1.1.53

Application

Application Comment Organism
pharmacology side-effects of pharmacologically active decarboxylation products considered Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
5-Aminooxymethyl-2-bromophenol brocresine, 75 mg/kg body mass cause 98% inhibition of liver enzyme in vivo Rattus norvegicus
N1-(DL-Seryl)-N2-(2,3,4)-trihydroxybenzyl hydrazine 50 mg/kg cause 99% inhibition of liver enzyme in vivo Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Phenylalanine Rattus norvegicus
-
 ?
-
 ?
Tryptophan Rattus norvegicus
-
 ?
-
 ?
Tyrosine Rattus norvegicus
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 human
-
Rattus norvegicus
-
 rat
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Rattus norvegicus
-
kidney
-
 Rattus norvegicus
-
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Phenylalanine
-
 Rattus norvegicus ?
-
 ?
Tryptophan
-
 Rattus norvegicus ?
-
 ?
Tyrosine
-
 Rattus norvegicus ?
-
 ?

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
 Homo sapiens
pyridoxal 5'-phosphate
-
 Rattus norvegicus