Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Benzene | stimulates decarboxylation of natural amino acids | Cavia aperea |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
5-hydroxytryptophan | complete inhibition at 0.001 mM | Cavia aperea | |
alpha-Methyl-3,4-dihydroxyphenylalanine | competitive | Cavia aperea | |
alpha-Methyl-5-hydroxyphenylalanine | - |
Cavia aperea | |
alpha-Methyl-m-tyrosine | - |
Cavia aperea | |
alpha-Methyltryptophan | - |
Cavia aperea | |
p-chloromercuribenzoate | complete inhibition at 0.01 mM | Cavia aperea |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.002 | - |
5-hydroxytryptophan | - |
Cavia aperea | |
0.04 | - |
3,4-dihydroxyphenylalanine | - |
Cavia aperea | |
0.3 | - |
tryptophan | - |
Cavia aperea | |
1.3 | - |
p-tyrosine | - |
Cavia aperea | |
2 | - |
phenylalanine | - |
Cavia aperea | |
2.2 | - |
histidine | - |
Cavia aperea |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Cavia aperea | involved in amine formation from natural amino acids prior to excretion | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Canis lupus | - |
dog | - |
Cavia aperea | - |
guinea pig | - |
Purification (Comment) | Organism |
---|---|
- |
Cavia aperea |
brain stem enzyme, partial | Canis lupus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Canis lupus | - |
kidney | - |
Cavia aperea | - |
kidney | - |
Canis lupus | - |
liver | - |
Cavia aperea | - |
liver | - |
Canis lupus | - |
stomach | - |
Cavia aperea | - |
Storage Stability | Organism |
---|---|
3¦C, 0.03 M phosphate buffer, pH 7, 40% loss of activity after 10 days, purified enzyme | Cavia aperea |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3,4-Dihydroxyphenylalanine | - |
Cavia aperea | Dopamine + CO2 | - |
? | |
3,4-Dihydroxyphenylalanine | - |
Canis lupus | Dopamine + CO2 | - |
? | |
5-Hydroxytryptophan | - |
Cavia aperea | Serotonin + CO2 | - |
? | |
5-Hydroxytryptophan | - |
Canis lupus | Serotonin + CO2 | - |
? | |
Histidine | - |
Cavia aperea | Histamine + CO2 | - |
? | |
Histidine | - |
Canis lupus | Histamine + CO2 | - |
? | |
L-phenylalanine | - |
Cavia aperea | phenylethylamine + CO2 | - |
? | |
L-phenylalanine | - |
Canis lupus | phenylethylamine + CO2 | - |
? | |
L-Tyrosine | - |
Cavia aperea | Tyramine + CO2 | - |
? | |
L-Tyrosine | - |
Canis lupus | Tyramine + CO2 | - |
? | |
additional information | involved in amine formation from natural amino acids prior to excretion | Cavia aperea | ? | - |
? | |
Tryptophan | - |
Cavia aperea | Tryptamine + CO2 | - |
? | |
Tryptophan | - |
Canis lupus | Tryptamine + CO2 | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
enzyme assay at | Cavia aperea |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
9 | - |
- |
Cavia aperea |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
pyridoxal 5'-phosphate | - |
Cavia aperea | |
pyridoxal 5'-phosphate | - |
Canis lupus |