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Literature summary for 4.1.1.53 extracted from
- Aromatic L-amino acid decarboxylase (1962), J. Biol. Chem., 237, 89-93.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| Benzene | stimulates decarboxylation of natural amino acids | Cavia aperea |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 5-hydroxytryptophan | complete inhibition at 0.001 mM | Cavia aperea | |
| alpha-Methyl-3,4-dihydroxyphenylalanine | competitive | Cavia aperea | |
| alpha-Methyl-5-hydroxyphenylalanine | - |
Cavia aperea | |
| alpha-Methyl-m-tyrosine | - |
Cavia aperea | |
| alpha-Methyltryptophan | - |
Cavia aperea | |
| p-chloromercuribenzoate | complete inhibition at 0.01 mM | Cavia aperea | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.002 | - |
5-hydroxytryptophan | - |
Cavia aperea | |
| 0.04 | - |
3,4-dihydroxyphenylalanine | - |
Cavia aperea | |
| 0.3 | - |
tryptophan | - |
Cavia aperea | |
| 1.3 | - |
p-tyrosine | - |
Cavia aperea | |
| 2 | - |
phenylalanine | - |
Cavia aperea | |
| 2.2 | - |
histidine | - |
Cavia aperea | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Cavia aperea | involved in amine formation from natural amino acids prior to excretion | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Canis lupus | - |
dog | - |
| Cavia aperea | - |
guinea pig | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Cavia aperea |
| brain stem enzyme, partial | Canis lupus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Canis lupus | - |
| kidney | - |
Cavia aperea | - |
| kidney | - |
Canis lupus | - |
| liver | - |
Cavia aperea | - |
| liver | - |
Canis lupus | - |
| stomach | - |
Cavia aperea | - |
Storage Stability
| Storage Stability | Organism |
|---|---|
| 3¦C, 0.03 M phosphate buffer, pH 7, 40% loss of activity after 10 days, purified enzyme | Cavia aperea |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3,4-Dihydroxyphenylalanine | - |
Cavia aperea | Dopamine + CO2 | - |
? | |
| 3,4-Dihydroxyphenylalanine | - |
Canis lupus | Dopamine + CO2 | - |
? | |
| 5-Hydroxytryptophan | - |
Cavia aperea | Serotonin + CO2 | - |
? | |
| 5-Hydroxytryptophan | - |
Canis lupus | Serotonin + CO2 | - |
? | |
| Histidine | - |
Cavia aperea | Histamine + CO2 | - |
? | |
| Histidine | - |
Canis lupus | Histamine + CO2 | - |
? | |
| L-phenylalanine | - |
Cavia aperea | phenylethylamine + CO2 | - |
? | |
| L-phenylalanine | - |
Canis lupus | phenylethylamine + CO2 | - |
? | |
| L-Tyrosine | - |
Cavia aperea | Tyramine + CO2 | - |
? | |
| L-Tyrosine | - |
Canis lupus | Tyramine + CO2 | - |
? | |
| additional information | involved in amine formation from natural amino acids prior to excretion | Cavia aperea | ? | - |
? | |
| Tryptophan | - |
Cavia aperea | Tryptamine + CO2 | - |
? | |
| Tryptophan | - |
Canis lupus | Tryptamine + CO2 | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
enzyme assay at | Cavia aperea |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 9 | - |
- |
Cavia aperea |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| pyridoxal 5'-phosphate | - |
Cavia aperea | |
| pyridoxal 5'-phosphate | - |
Canis lupus | |
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Release 2023.1 (January 2023)
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