BRENDA - Enzyme Database
show all sequences of 4.1.1.53

Aromatic L-amino acid decarboxylase

Lovenberg, W.; Weissbach, H.; Udenfriend, S.; J. Biol. Chem. 237, 89-93 (1962)

Data extracted from this reference:

Activating Compound
Activating Compound
Commentary
Organism
Structure
Benzene
stimulates decarboxylation of natural amino acids
Cavia aperea
Inhibitors
Inhibitors
Commentary
Organism
Structure
5-hydroxytryptophan
complete inhibition at 0.001 mM
Cavia aperea
alpha-Methyl-3,4-dihydroxyphenylalanine
competitive
Cavia aperea
alpha-Methyl-5-hydroxyphenylalanine
-
Cavia aperea
alpha-Methyl-m-tyrosine
-
Cavia aperea
alpha-Methyltryptophan
-
Cavia aperea
p-chloromercuribenzoate
complete inhibition at 0.01 mM
Cavia aperea
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.002
-
5-hydroxytryptophan
-
Cavia aperea
0.04
-
3,4-dihydroxyphenylalanine
-
Cavia aperea
0.3
-
tryptophan
-
Cavia aperea
1.3
-
p-tyrosine
-
Cavia aperea
2
-
phenylalanine
-
Cavia aperea
2.2
-
histidine
-
Cavia aperea
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
additional information
Cavia aperea
involved in amine formation from natural amino acids prior to excretion
?
-
-
-
Organism
Organism
UniProt
Commentary
Textmining
Canis lupus
-
dog
-
Cavia aperea
-
guinea pig
-
Purification (Commentary)
Purification (Commentary)
Organism
-
Cavia aperea
brain stem enzyme, partial
Canis lupus
Source Tissue
Source Tissue
Commentary
Organism
Textmining
brain
-
Canis lupus
-
kidney
-
Canis lupus
-
kidney
-
Cavia aperea
-
liver
-
Canis lupus
-
liver
-
Cavia aperea
-
stomach
-
Cavia aperea
-
Storage Stability
Storage Stability
Organism
3C, 0.03 M phosphate buffer, pH 7, 40% loss of activity after 10 days, purified enzyme
Cavia aperea
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
3,4-Dihydroxyphenylalanine
-
4704
Cavia aperea
Dopamine + CO2
-
-
-
-
3,4-Dihydroxyphenylalanine
-
4704
Canis lupus
Dopamine + CO2
-
-
-
-
5-Hydroxytryptophan
-
4704
Cavia aperea
Serotonin + CO2
-
-
-
-
5-Hydroxytryptophan
-
4704
Canis lupus
Serotonin + CO2
-
-
-
-
Histidine
-
4704
Cavia aperea
Histamine + CO2
-
-
-
-
Histidine
-
4704
Canis lupus
Histamine + CO2
-
-
-
-
L-phenylalanine
-
4704
Cavia aperea
phenylethylamine + CO2
-
-
-
-
L-phenylalanine
-
4704
Canis lupus
phenylethylamine + CO2
-
-
-
-
L-Tyrosine
-
4704
Cavia aperea
Tyramine + CO2
-
-
-
-
L-Tyrosine
-
4704
Canis lupus
Tyramine + CO2
-
-
-
-
additional information
involved in amine formation from natural amino acids prior to excretion
4704
Cavia aperea
?
-
-
-
-
Tryptophan
-
4704
Cavia aperea
Tryptamine + CO2
-
-
-
-
Tryptophan
-
4704
Canis lupus
Tryptamine + CO2
-
-
-
-
Temperature Optimum [C]
Temperature Optimum [C]
Temperature Optimum Maximum [C]
Commentary
Organism
37
-
enzyme assay at
Cavia aperea
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
9
-
-
Cavia aperea
Cofactor
Cofactor
Commentary
Organism
Structure
pyridoxal 5'-phosphate
-
Canis lupus
pyridoxal 5'-phosphate
-
Cavia aperea
Activating Compound (protein specific)
Activating Compound
Commentary
Organism
Structure
Benzene
stimulates decarboxylation of natural amino acids
Cavia aperea
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
pyridoxal 5'-phosphate
-
Canis lupus
pyridoxal 5'-phosphate
-
Cavia aperea
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
5-hydroxytryptophan
complete inhibition at 0.001 mM
Cavia aperea
alpha-Methyl-3,4-dihydroxyphenylalanine
competitive
Cavia aperea
alpha-Methyl-5-hydroxyphenylalanine
-
Cavia aperea
alpha-Methyl-m-tyrosine
-
Cavia aperea
alpha-Methyltryptophan
-
Cavia aperea
p-chloromercuribenzoate
complete inhibition at 0.01 mM
Cavia aperea
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.002
-
5-hydroxytryptophan
-
Cavia aperea
0.04
-
3,4-dihydroxyphenylalanine
-
Cavia aperea
0.3
-
tryptophan
-
Cavia aperea
1.3
-
p-tyrosine
-
Cavia aperea
2
-
phenylalanine
-
Cavia aperea
2.2
-
histidine
-
Cavia aperea
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
additional information
Cavia aperea
involved in amine formation from natural amino acids prior to excretion
?
-
-
-
Purification (Commentary) (protein specific)
Commentary
Organism
-
Cavia aperea
brain stem enzyme, partial
Canis lupus
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
brain
-
Canis lupus
-
kidney
-
Canis lupus
-
kidney
-
Cavia aperea
-
liver
-
Canis lupus
-
liver
-
Cavia aperea
-
stomach
-
Cavia aperea
-
Storage Stability (protein specific)
Storage Stability
Organism
3C, 0.03 M phosphate buffer, pH 7, 40% loss of activity after 10 days, purified enzyme
Cavia aperea
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
3,4-Dihydroxyphenylalanine
-
4704
Cavia aperea
Dopamine + CO2
-
-
-
-
3,4-Dihydroxyphenylalanine
-
4704
Canis lupus
Dopamine + CO2
-
-
-
-
5-Hydroxytryptophan
-
4704
Cavia aperea
Serotonin + CO2
-
-
-
-
5-Hydroxytryptophan
-
4704
Canis lupus
Serotonin + CO2
-
-
-
-
Histidine
-
4704
Cavia aperea
Histamine + CO2
-
-
-
-
Histidine
-
4704
Canis lupus
Histamine + CO2
-
-
-
-
L-phenylalanine
-
4704
Cavia aperea
phenylethylamine + CO2
-
-
-
-
L-phenylalanine
-
4704
Canis lupus
phenylethylamine + CO2
-
-
-
-
L-Tyrosine
-
4704
Cavia aperea
Tyramine + CO2
-
-
-
-
L-Tyrosine
-
4704
Canis lupus
Tyramine + CO2
-
-
-
-
additional information
involved in amine formation from natural amino acids prior to excretion
4704
Cavia aperea
?
-
-
-
-
Tryptophan
-
4704
Cavia aperea
Tryptamine + CO2
-
-
-
-
Tryptophan
-
4704
Canis lupus
Tryptamine + CO2
-
-
-
-
Temperature Optimum [C] (protein specific)
Temperature Optimum [C]
Temperature Optimum Maximum [C]
Commentary
Organism
37
-
enzyme assay at
Cavia aperea
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
9
-
-
Cavia aperea
Other publictions for EC 4.1.1.53
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Synonyms
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
746609
Sytykiewicz
-
Methyl jasmonate elicitation ...
Zea mays subsp. mays
Acta Biol. Crac. Ser. Bot.
58
67-80
2016
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1
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2
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2
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3
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2
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8
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2
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2
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6
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2
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1
1
2
2
-
-
748581
Sim
Bacterial synthesis of N-hydr ...
Pseudomonas putida, Pseudomonas putida ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440
Microb. Cell Fact.
14
162
2015
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1
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1
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2
-
2
-
-
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-
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4
-
2
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1
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1
1
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1
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2
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4
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728786
Stevenson
Expression of the DisA amino a ...
Proteus mirabilis
Res. Microbiol.
164
31-37
2013
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4
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1
1
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679891
Marcobal
First genetic characterization ...
Enterococcus faecium
FEMS Microbiol. Lett.
258
144-149
2006
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1
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-
-
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4
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1
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2
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1
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1
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1
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2
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654188
Ziadeh
Enzymatic decarboxylation of t ...
Enterococcus faecalis
Anal. Chem.
74
479-483
2002
-
1
-
-
-
-
-
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1
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1
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-
-
-
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-
4707
Buckberry
-
Cysteine conjugate beta-lyase ...
Enterococcus faecalis
Biochem. Soc. Trans.
26
269
1998
-
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-
-
-
-
-
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1
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1
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1
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1
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1
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1
-
1
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-
-
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-
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-
-
-
-
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-
4231
Jebai
Expression, purification, and ...
Rattus norvegicus
Protein Expr. Purif.
11
185-194
1997
-
-
1
-
-
-
-
2
-
-
-
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1
-
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1
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3
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2
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1
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1
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2
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1
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3
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2
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1
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-
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-
-
-
-
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-
4709
Taylor
-
Metabolism of D,L-chlorophenyl ...
no activity in Papaver somniferum, Phaseolus vulgaris
Biochemistry
26
1279-1288
1987
-
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2
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1
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2
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1
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1
2
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4706
Chen
A rapid procedure for detectio ...
Morganella morganii
Anal. Biochem.
111
60-66
1981
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1
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1
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1
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1
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1
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4708
Nakazawa
-
Distribution and formation of ...
Achromobacter sp., Micrococcus percitreus, Micrococcus sp., Sarcina sp., Staphylococcus sp.
Agric. Biol. Chem.
41
2241-2247
1977
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1
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1
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5
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1
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21
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5
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5
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5
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5
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1
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1
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1
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21
-
5
-
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5
-
-
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-
-
-
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-
4705
David
On the importance of decarboxy ...
Homo sapiens, Rattus norvegicus
Arch. Biochem. Biophys.
160
561-568
1974
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1
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2
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3
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2
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3
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3
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2
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1
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2
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2
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3
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3
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3
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4704
Lovenberg
Aromatic L-amino acid decarbox ...
Canis lupus, Cavia aperea
J. Biol. Chem.
237
89-93
1962
1
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6
6
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1
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2
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2
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6
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1
13
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1
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1
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2
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1
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2
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6
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6
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1
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2
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6
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1
13
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1
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1
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