Literature summary for 4.1.1.50 extracted from

Barker, R.H.; Liu, H.; Hirth, B.; Celatka, C.A.; Fitzpatrick, R.; Xiang, Y.; Willert, E.K.; Phillips, M.A.; Kaiser, M.; Bacchi, C.J.; Rodriguez, A.; Yarlett, N.; Klinger, J.D.; Sybertz, E.
Novel S-adenosylmethionine decarboxylase inhibitors for the treatment of human African trypanosomiasis (2009), Antimicrob. Agents Chemother., 53, 2052-2058.

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Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Escherichia coli	Homo sapiens
expressed in Escherichia coli	Trypanosoma brucei

Inhibitors

Inhibitors	Comment	Organism	Structure
Genz-643990	-	Homo sapiens
Genz-643990	-	Trypanosoma brucei
Genz-644043	-	Homo sapiens
Genz-644043	-	Trypanosoma brucei
Genz-644053	-	Homo sapiens
Genz-644053	-	Trypanosoma brucei
Genz-644131	-	Homo sapiens
Genz-644131	-	Trypanosoma brucei
MDL73811	irreversible inhibitor	Homo sapiens
MDL73811	irreversible inhibitor	Trypanosoma brucei

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-
Trypanosoma brucei	-	subspecies Trypanosoma brucei rhodesiense strain STIB 900 and subspecies Trypanosoma brucei brucei strains LAB 110 EATRO and STIB 795	-

Purification (Commentary)

Purification (Comment)	Organism
Ni2+-agarose column chromatography	Homo sapiens
Ni2+-agarose column chromatography	Trypanosoma brucei

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
S-adenosyl-L-methionine	-	Homo sapiens	(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2	-	?
S-adenosyl-L-methionine	-	Trypanosoma brucei	(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2	-	?

Synonyms

Synonyms	Comment	Organism
AdoMetDC	-	Homo sapiens
AdoMetDC	-	Trypanosoma brucei
S-Adenosylmethionine decarboxylase	-	Homo sapiens
S-Adenosylmethionine decarboxylase	-	Trypanosoma brucei

Cofactor

Cofactor	Comment	Organism	Structure
pyridoxal 5'-phosphate	-	Homo sapiens
pyridoxal 5'-phosphate	-	Trypanosoma brucei

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Release 2023.1 (January 2023)