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Literature summary for 4.1.1.50 extracted from

  • Bale, S.; Ealick, S.E.
    Structural biology of S-adenosylmethionine decarboxylase (2010), Amino Acids, 38, 451-460.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
putrescine
-
Homo sapiens

Crystallization (Commentary)

Crystallization (Comment) Organism
-
Trypanosoma brucei
-
Homo sapiens
-
Thermotoga maritima
-
Solanum tuberosum
-
Aquifex aeolicus

Protein Variants

Protein Variants Comment Organism
C82A the mutant shows decreased kcat compared to the wild type enzyme Homo sapiens
H243A the mutation traps the enzyme in the ester form Homo sapiens
S68A themutant lacks the hydroxyl group necessary for processing and traps the enzyme in a form similar to the proenzyme Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
4-amidinoindan-1-one-2'-amidinohydrazone
-
Aquifex aeolicus
4-amidinoindan-1-one-2'-amidinohydrazone
-
Homo sapiens
4-amidinoindan-1-one-2'-amidinohydrazone
-
Solanum tuberosum
4-amidinoindan-1-one-2'-amidinohydrazone
-
Thermotoga maritima
4-amidinoindan-1-one-2'-amidinohydrazone
-
Trypanosoma brucei
5'-deoxy-5'-(dimethyl-sulfonio)adenosine
-
Aquifex aeolicus
5'-deoxy-5'-(dimethyl-sulfonio)adenosine
-
Homo sapiens
5'-deoxy-5'-(dimethyl-sulfonio)adenosine
-
Solanum tuberosum
5'-deoxy-5'-(dimethyl-sulfonio)adenosine
-
Thermotoga maritima
5'-deoxy-5'-(dimethyl-sulfonio)adenosine
-
Trypanosoma brucei
5'-deoxy-5'-(N-dimethyl)amino-8-methyl adenosine
-
Aquifex aeolicus
5'-deoxy-5'-(N-dimethyl)amino-8-methyl adenosine
-
Homo sapiens
5'-deoxy-5'-(N-dimethyl)amino-8-methyl adenosine
-
Solanum tuberosum
5'-deoxy-5'-(N-dimethyl)amino-8-methyl adenosine
-
Thermotoga maritima
5'-deoxy-5'-(N-dimethyl)amino-8-methyl adenosine
-
Trypanosoma brucei
5'-deoxy-5'-[N-methyl-N-(3-hydrazino-propyl)amino]adenosine
-
Aquifex aeolicus
5'-deoxy-5'-[N-methyl-N-(3-hydrazino-propyl)amino]adenosine
-
Homo sapiens
5'-deoxy-5'-[N-methyl-N-(3-hydrazino-propyl)amino]adenosine
-
Solanum tuberosum
5'-deoxy-5'-[N-methyl-N-(3-hydrazino-propyl)amino]adenosine
-
Thermotoga maritima
5'-deoxy-5'-[N-methyl-N-(3-hydrazino-propyl)amino]adenosine
-
Trypanosoma brucei
5'-deoxy-5'-[N-methyl-N-[(2-aminooxy)-ethyl]amino]adenosine
-
Aquifex aeolicus
5'-deoxy-5'-[N-methyl-N-[(2-aminooxy)-ethyl]amino]adenosine
-
Homo sapiens
5'-deoxy-5'-[N-methyl-N-[(2-aminooxy)-ethyl]amino]adenosine
-
Solanum tuberosum
5'-deoxy-5'-[N-methyl-N-[(2-aminooxy)-ethyl]amino]adenosine
-
Thermotoga maritima
5'-deoxy-5'-[N-methyl-N-[(2-aminooxy)-ethyl]amino]adenosine
-
Trypanosoma brucei
CGP48664A i.e. 4-amidinoindan-1-one-2'-amidinohydrazone Aquifex aeolicus
CGP48664A i.e. 4-amidinoindan-1-one-2'-amidinohydrazone Homo sapiens
CGP48664A i.e. 4-amidinoindan-1-one-2'-amidinohydrazone Solanum tuberosum
CGP48664A i.e. 4-amidinoindan-1-one-2'-amidinohydrazone Thermotoga maritima
CGP48664A i.e. 4-amidinoindan-1-one-2'-amidinohydrazone Trypanosoma brucei
methylglyoxalbis(guanylhydrazone)
-
Aquifex aeolicus
methylglyoxalbis(guanylhydrazone)
-
Homo sapiens
methylglyoxalbis(guanylhydrazone)
-
Solanum tuberosum
methylglyoxalbis(guanylhydrazone)
-
Thermotoga maritima
methylglyoxalbis(guanylhydrazone)
-
Trypanosoma brucei

Organism

Organism UniProt Comment Textmining
Aquifex aeolicus O66615
-
-
Homo sapiens P17707
-
-
Solanum tuberosum Q04694
-
-
Thermotoga maritima Q9WZC3
-
-
Trypanosoma brucei
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
additional information AdoMetDC is expressed as an inactive proenzyme that undergoes autoprocessing to the active enzyme. The autoprocessing involves an internal serinolysis reaction leading to the cleavage of the backbone to alpha and beta subunits with the latter being the smaller subunit and to generation of a pyruvoyl group at the N-terminus of the alpha chain Trypanosoma brucei
additional information AdoMetDC is expressed as an inactive proenzyme that undergoes autoprocessing to the active enzyme. The autoprocessing involves an internal serinolysis reaction leading to the cleavage of the backbone to alpha and beta subunits with the latter being the smaller subunit and to generation of a pyruvoyl group at the N-terminus of the alpha chain Homo sapiens
additional information AdoMetDC is expressed as an inactive proenzyme that undergoes autoprocessing to the active enzyme. The autoprocessing involves an internal serinolysis reaction leading to the cleavage of the backbone to alpha and beta subunits with the latter being the smaller subunit and to generation of a pyruvoyl group at the N-terminus of the alpha chain Thermotoga maritima
additional information AdoMetDC is expressed as an inactive proenzyme that undergoes autoprocessing to the active enzyme. The autoprocessing involves an internal serinolysis reaction leading to the cleavage of the backbone to alpha and beta subunits with the latter being the smaller subunit and to generation of a pyruvoyl group at the N-terminus of the alpha chain Solanum tuberosum
additional information AdoMetDC is expressed as an inactive proenzyme that undergoes autoprocessing to the active enzyme. The autoprocessing involves an internal serinolysis reaction leading to the cleavage of the backbone to alpha and beta subunits with the latter being the smaller subunit and to generation of a pyruvoyl group at the N-terminus of the alpha chain Aquifex aeolicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine
-
Trypanosoma brucei (5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
?
S-adenosyl-L-methionine
-
Homo sapiens (5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
?
S-adenosyl-L-methionine
-
Thermotoga maritima (5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
?
S-adenosyl-L-methionine
-
Solanum tuberosum (5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
?
S-adenosyl-L-methionine
-
Aquifex aeolicus (5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
?

Subunits

Subunits Comment Organism
dimer x-ray crystallography Trypanosoma brucei
dimer x-ray crystallography Homo sapiens
dimer x-ray crystallography Thermotoga maritima
dimer x-ray crystallography Solanum tuberosum
dimer x-ray crystallography Aquifex aeolicus

Synonyms

Synonyms Comment Organism
AdoMetDC
-
Trypanosoma brucei
AdoMetDC
-
Homo sapiens
AdoMetDC
-
Thermotoga maritima
AdoMetDC
-
Solanum tuberosum
AdoMetDC
-
Aquifex aeolicus
S-Adenosylmethionine decarboxylase
-
Trypanosoma brucei
S-Adenosylmethionine decarboxylase
-
Homo sapiens
S-Adenosylmethionine decarboxylase
-
Thermotoga maritima
S-Adenosylmethionine decarboxylase
-
Solanum tuberosum
S-Adenosylmethionine decarboxylase
-
Aquifex aeolicus

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
Trypanosoma brucei
pyridoxal 5'-phosphate
-
Homo sapiens
pyridoxal 5'-phosphate
-
Thermotoga maritima
pyridoxal 5'-phosphate
-
Solanum tuberosum
pyridoxal 5'-phosphate
-
Aquifex aeolicus
thiamine diphosphate
-
Trypanosoma brucei
thiamine diphosphate
-
Homo sapiens
thiamine diphosphate
-
Thermotoga maritima
thiamine diphosphate
-
Solanum tuberosum
thiamine diphosphate
-
Aquifex aeolicus