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Literature summary for 4.1.1.50 extracted from
- The polycyclic aromatic hydrocarbon phenanthrene causes oxidative stress and alters polyamine metabolism in the aquatic liverwort Riccia fluitans L (2008), Plant Cell Environ., 31, 1416-1431.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | DL-alpha-difluoromethylornithine does not influence the general trend of increased SAMDC activity observed in plants exposed to 0.1 or 0.5 microM phenanthrene | Riccia fluitans | |
| phenanthrene | concentrations of phenanthrene up to 0.5 microM cause significant increases in the activity of SAMDC, with a resultant increase in tissue polyamine levels | Riccia fluitans |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| methylglyoxal-bis(guanylhydrazone) | in the absence of phenanthrene, treatment with 2.0 mM methylglyoxal-bis(guanylhydrazone) inhibits SAMDC activity by 73% | Riccia fluitans | |
| additional information | inhibition of SAMDC by methylglyoxal-bis(guanylhydrazone), and hence reduced spermidine and spermine synthesis limits the ability of plants to recover following exposure to phenanthrene to a slightly greater extent than inhibition of arginine decarboxylase; inhibition of SAMDC results in much greater levels of oxidative damage than seen in plants treated with 0.5 microM phenanthrene; treatment of plants exposed to phenanthrene with DL-alpha-difluoromethylarginine does not result in any major changes to the trends in SAMDC activity observed in plants exposed to phenanthrene | Riccia fluitans |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Riccia fluitans | synthesis of the triamine spermidine and the tetramine spermine is achieved by the sequential addition of aminopropyl moieties from decarboxylated S-adenosylmethionine, synthesized by the enzyme S-adenosylmethionine decarboxylase | ? | - |
? | |
| S-adenosyl-L-methionine | Riccia fluitans | - |
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Riccia fluitans | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| thallus | - |
Riccia fluitans | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | synthesis of the triamine spermidine and the tetramine spermine is achieved by the sequential addition of aminopropyl moieties from decarboxylated S-adenosylmethionine, synthesized by the enzyme S-adenosylmethionine decarboxylase | Riccia fluitans | ? | - |
? | |
| S-adenosyl-L-methionine | - |
Riccia fluitans | (5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| S-Adenosylmethionine decarboxylase | - |
Riccia fluitans |
| SAMDC | - |
Riccia fluitans |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
assay at | Riccia fluitans |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.6 | - |
assay at | Riccia fluitans |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| pyridoxal 5'-phosphate | - |
Riccia fluitans | |
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Release 2023.1 (January 2023)
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