Literature summary for 4.1.1.50 extracted from

Ndjonka, D.; Zou, Y.; Bi, X.; Woster, P.; Walter, R.D.; Luersen, K.
The activator-binding site of Onchocerca volvulus S-adenosylmethionine decarboxylase, a potential drug target (2003), Biol. Chem., 384, 1195-1201.

Search for more literature for 4.1.1.50

Activating Compound

Activating Compound	Comment	Organism	Structure
1,15-diamino-4,12-diazapentadecane	-	Onchocerca volvulus
1,5-Diaminopentane	57% of activation by putrescine	Onchocerca volvulus
1,6-diaminohexane	58% of activation by putrescine	Onchocerca volvulus
1,7-Diaminoheptane	45% of activation by putrescine	Onchocerca volvulus
33-003	-	Onchocerca volvulus
N1-acetylspermidine	60% of activation by putrescine	Onchocerca volvulus
PMW-2000-11-13-5	-	Onchocerca volvulus
putrescine	-	Onchocerca volvulus
spermidine	82% of activation by putrescine	Onchocerca volvulus
spermine	13% of activation by putrescine	Onchocerca volvulus
YZ-33-046	-	Onchocerca volvulus
YZ-33-050C	-	Onchocerca volvulus

Inhibitors

Inhibitors	Comment	Organism	Structure
BW-1	85% inhibition at 2 mM, in presence of 2 mM putrescine, degree of inhibition depends on actual putrescine abundance	Homo sapiens
BW-1	99% inhibition at 2 mM, in presence of 2 mM putrescine, degree of inhibition depends on actual putrescine abundance	Onchocerca volvulus
MDL 27695	44% inhibition at 2 mM, in presence of 2 mM putrescine	Homo sapiens
MDL 27695	86% inhibition at 2 mM, in presence of 2 mM putrescine	Onchocerca volvulus
PMW-2000-11-13-1	52% inhibition at 2 mM, in presence of 2 mM putrescine	Homo sapiens
PMW-2000-11-13-1	97% inhibition at 2 mM, in presence of 2 mM putrescine	Onchocerca volvulus
RHW-17-69-75	45% inhibition at 2 mM, in presence of 2 mM putrescine	Homo sapiens
RHW-17-69-75	97% inhibition at 2 mM, in presence of 2 mM putrescine	Onchocerca volvulus

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-
Onchocerca volvulus	-	-	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
1.3	-	without activator	Onchocerca volvulus
8	-	plus 2 mM 1,15-diamino-4,12-diazapentadecane	Onchocerca volvulus
8	-	plus 2 mM 33-003	Onchocerca volvulus
19	-	pus 2 mM YZ-33-050C	Onchocerca volvulus
26	-	plus 2 mM PMW-2000-11-13-5	Onchocerca volvulus
46	-	plus 2 mM YZ-33-046	Onchocerca volvulus
79	-	plus 2 mM putrescine	Onchocerca volvulus
121	-	plus 2 mM YZ-33-050C	Homo sapiens
148	-	plus 2 mM 33-003	Homo sapiens
152	-	plus 2 mM PMW-2000-11-13-5	Homo sapiens
176	-	plus 2 mM YZ-33-046	Homo sapiens
180	-	plus 2 mM 1,15-diamono-4,12-diazapentadecane	Homo sapiens
410	-	plus 2 mM putrescine	Homo sapiens

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Release 2023.1 (January 2023)