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Literature summary for 4.1.1.50 extracted from

  • White, E.L.; Arnett, G.; Secrist III, J.A.; Shannon, W.M.
    Characterization of S-adenosylmethionine decarboxylase induced by human cytomegalovirus infection (1994), Virus Res., 31, 255-263.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
putrescine stimulation Homo sapiens

General Stability

General Stability Organism
freezing inactivates Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
5'-Deoxy-5'-[(3-hydrazinopropyl)methylamino]adenosine
-
Homo sapiens
additional information unaffected by divalent cations Homo sapiens
NaCl enzyme from infected cells is unaffected up to 0.8 M, 50% inhibition of the enzyme from uninfected cells at 0.45 M Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.146
-
S-adenosyl-L-methionine enzyme from infected cells Homo sapiens
0.245
-
S-adenosyl-L-methionine enzyme from uninfected cells Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
additional information unaffected by divalent cations Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine Homo sapiens key enzyme in polyamine biosynthesis ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
lung MRC5, diploid, embryonic, uninfected or infected with cytomegalovirus Homo sapiens
-

Storage Stability

Storage Stability Organism
4°C, stable for up to 2 weeks Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine
-
Homo sapiens (5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
?
S-adenosyl-L-methionine key enzyme in polyamine biosynthesis Homo sapiens ?
-
?

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
47
-
10 min, 50% loss of activity Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.2 7.4
-
Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.45
-
NaCl inhibition of the enzyme from uninfected cells Homo sapiens
0.45
-
NaCl enzyme from infected cells is unaffected up to 0.8 M Homo sapiens