Activating Compound | Comment | Organism | Structure |
---|---|---|---|
isoleucine | requirement for branched-chain amino acids, control of the pool of alpha-acetolactate by valine, leucine and isoleucine via allosteric activation, valine is more stimulatory than leucine and isoleucine | Streptococcus thermophilus | |
leucine | requirement for branched-chain amino acids, control of the pool of alpha-acetolactate by valine, leucine and isoleucine via allosteric activation, valine is more stimulatory than leucine and isoleucine | Streptococcus thermophilus | |
valine | requirement for branched-chain amino acids, control of the pool of alpha-acetolactate by valine, leucine and isoleucine via allosteric activation, valine is more stimulatory than leucine and isoleucine | Streptococcus thermophilus |
Cloned (Comment) | Organism |
---|---|
aldC gene, expression in Escherichia coli | Streptococcus thermophilus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | alpha-acetolactate decarboxylase-deficient mutant TIL865 | Streptococcus thermophilus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
(S)-2-hydroxy-2-methyl-3-oxobutanoate | Streptococcus thermophilus | regulates leucine and valine biosynthesis by diverting the flux of alpha-acetolactate towards acetoin when branched-chain amino acids are present at a high concentration, involved in catabolism of pyruvate to acetoin, but less important function in vivo | (R)-acetoin + CO2 | - |
? | |
(S)-2-hydroxy-2-methyl-3-oxobutanoate | Streptococcus thermophilus CNRZ385 | regulates leucine and valine biosynthesis by diverting the flux of alpha-acetolactate towards acetoin when branched-chain amino acids are present at a high concentration, involved in catabolism of pyruvate to acetoin, but less important function in vivo | (R)-acetoin + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Streptococcus thermophilus | Q8L208 | - |
- |
Streptococcus thermophilus CNRZ385 | Q8L208 | - |
- |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.27 | - |
culture in the presence of leucine and isoleucine | Streptococcus thermophilus |
0.472 | - |
culture in the presence of leucine and valine | Streptococcus thermophilus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(S)-2-hydroxy-2-methyl-3-oxobutanoate | - |
Streptococcus thermophilus | (R)-acetoin + CO2 | - |
? | |
(S)-2-hydroxy-2-methyl-3-oxobutanoate | regulates leucine and valine biosynthesis by diverting the flux of alpha-acetolactate towards acetoin when branched-chain amino acids are present at a high concentration, involved in catabolism of pyruvate to acetoin, but less important function in vivo | Streptococcus thermophilus | (R)-acetoin + CO2 | - |
? | |
(S)-2-hydroxy-2-methyl-3-oxobutanoate | - |
Streptococcus thermophilus CNRZ385 | (R)-acetoin + CO2 | - |
? | |
(S)-2-hydroxy-2-methyl-3-oxobutanoate | regulates leucine and valine biosynthesis by diverting the flux of alpha-acetolactate towards acetoin when branched-chain amino acids are present at a high concentration, involved in catabolism of pyruvate to acetoin, but less important function in vivo | Streptococcus thermophilus CNRZ385 | (R)-acetoin + CO2 | - |
? | |
additional information | not: alpha-acetohydroxybutyrate | Streptococcus thermophilus | ? | - |
? | |
additional information | not: alpha-acetohydroxybutyrate | Streptococcus thermophilus CNRZ385 | ? | - |
? |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6 | - |
assay at | Streptococcus thermophilus |