Literature summary for 4.1.1.45 extracted from

Huo, L.; Fielding, A.J.; Chen, Y.; Li, T.; Iwaki, H.; Hosler, J.P.; Chen, L.; Hasegawa, Y.; Que, L.; Liu, A.
Evidence for a dual role of an active site histidine in alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase (2012), Biochemistry, 51, 5811-5821.

Search for more literature for 4.1.1.45

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Escherichia coli BL21(DE3) cells	Pseudomonas fluorescens

Crystallization (Commentary)

Crystallization (Comment)	Organism
mutant enzymes Co(II)-H228Y, Zn(II)-H228Y, and Zn(II)-H228G, hanging drop vapor diffusion method, using 0.1 M Tris-HCl (pH 8.75), 0.2 M MgCl2, and 15% (w/v) PEG 5000	Pseudomonas fluorescens

Protein Variants

Protein Variants	Comment	Organism
H228G	the mutant contains iron rather than zinc and is catalytically inactive	Pseudomonas fluorescens
H228Y	the mutant contains iron rather than zinc and is catalytically inactive	Pseudomonas fluorescens

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Zn2+	contains zinc	Pseudomonas fluorescens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate	Pseudomonas fluorescens	-	2-aminomuconate semialdehyde + CO2	-	?

Organism

Organism	UniProt	Comment	Textmining
Pseudomonas fluorescens	Q83V25	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate	-	Pseudomonas fluorescens	2-aminomuconate semialdehyde + CO2	-	?

Synonyms

Synonyms	Comment	Organism
ACMSD	-	Pseudomonas fluorescens
alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase	-	Pseudomonas fluorescens

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Release 2023.1 (January 2023)