Application | Comment | Organism |
---|---|---|
drug development | inhibition of alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase should be explored as a possible novel therapeutic avenue for the treatment of diabetes | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
- |
Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
vapour diffusion technique in hanging drop, crystal structure of human alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase in complex with the glycolytic intermediate 1,3-dihydroxyacetonephosphate (DHAP), refined to an R-factor of 0.19, 1 mM DHAP, 2% poly(ethylene glycol) (PEG 400), 0.1 M Na/Hepes pH 7.5, 2.0 M ammonium sulphate, mixed with the same amount of a protein solution at a concentration of 12.7 mg/ml, and equilibrated against 500 microL of the reservoir solution, at 20°C | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,3-dihydroxyacetonephosphate | - |
Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate | Homo sapiens | - |
2-aminomuconate-6-semialdehyde + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q8TDX5 | - |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate | - |
Homo sapiens | 2-aminomuconate-6-semialdehyde + CO2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase | - |
Homo sapiens |
hACMSD | - |
Homo sapiens |