Literature summary for 4.1.1.45 extracted from

Shin, M.; Kim, I.; Inoue, Y.; Kimura, S.; Gonzalez, F.J.
Regulation of mouse hepatic alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase, a key enzyme in the tryptophan-nicotinamide adenine dinucleotide pathway, by hepatocyte nuclear factor 4alpha and peroxisome proliferator-activated receptor alpha (2006), Mol. Pharmacol., 70, 1281-1290.

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Activating Compound

Activating Compound	Comment	Organism	Structure
hepatocyte nuclear factor 4alpha	gene expression is activated by hepatocyte nuclear factor 4alpha	Mus musculus

Inhibitors

Inhibitors	Comment	Organism	Structure
peroxisome proliferator-activated receptor alpha	gene expression is downregulated by activation of peroxisome proliferator-activated receptor alpha	Mus musculus
[4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio]acetic acid	suppresses ACMSD activity	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2-amino-3-(3-oxoprop-2-enyl)-but-2-enedioate	-	Mus musculus	2-aminomuconate-6-semialdehyde + CO2	-	?

Synonyms

Synonyms	Comment	Organism
ACMSD	-	Mus musculus
alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase	-	Mus musculus

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Release 2023.1 (January 2023)