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Literature summary for 4.1.1.45 extracted from

  • Fukuwatari, T.; Ohsaki, S.; Fukuoka, S.; Sasaki, R.; Shibata, K.
    Phthalate esters enhance quinolinate production by inhibiting alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase (ACMSD), a key enzyme of the tryptophan pathway (2004), Toxicol. Sci., 81, 302-308.
    View publication on PubMed
Search for more literature for 4.1.1.45

Cloned(Commentary)

Cloned (Comment) Organism
expression in COS-7 cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
mono (2-ethyl hexyl) phthalate 90% inhibition of ACMSD activity in the presence of 3 mmol/l mono (2-ethyl hexyl) phthalate, inhibition is reversible Rattus norvegicus
mono (2-ethylhexyl) phthalate 92% inhibition of ACMSD activity in the presence of 3 mmol/l mono (2-ethyl hexyl) phthalate, inhibition is reversible Homo sapiens
mono (2-ethylhexyl) phthalate 93% inhibition of ACMSD activity in the presence of 3 mmol/l mono (2-ethyl hexyl) phthalate Mus musculus
mono-n-butyl phthalate 18% inhibition of ACMSD activity in the presence of 3 mmol/l mono-n-butyl phthalate Homo sapiens
mono-n-butyl phthalate 15% inhibition of ACMSD activity in the presence of 3 mmol/l mono-n-butyl phthalate Mus musculus
mono-n-butyl phthalate 20% inhibition of ACMSD activity in the presence of 3 mmol/l mono-n-butyl phthalate Rattus norvegicus
mono-n-hexyl phthalate 84% inhibition of ACMSD activity in the presence of 3 mmol/l mono-n-hexyl phthalate Homo sapiens
mono-n-hexyl phthalate 64% inhibition of ACMSD activity in the presence of 3 mmol/l mono-n-hexyl phthalate Mus musculus
mono-n-hexyl phthalate 60% inhibition of ACMSD activity in the presence of 3 mmol/l mono-n-hexyl phthalate Rattus norvegicus
additional information not inhibited by monoethyl phthalate Homo sapiens
additional information not inhibited by monoethyl phthalate Mus musculus
additional information not inhibited by monoethyl phthalate Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-
Rattus norvegicus
-
 Wistar rat
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
 Mus musculus
-
liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 3.07 micromol/h/g kidney, enzyme assay performed at 25°C, pH 8.0 and 50 mmol/l Tris-acetate buffer Mus musculus
additional information
-
 9.3 micromol/h/g liver, enzyme assay performed at 25°C, pH 8.0 and in 50 mmol/l Tris-acetate buffer Rattus norvegicus
0.36
-
 enzyme assay performed at 25°C, pH 8.0 and 50 mmol/l Tris-acetate buffer Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate
-
 Mus musculus 2-aminomuconate-6-semialdehyde + CO2
-
 ?
2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate
-
 Homo sapiens 2-aminomuconate-6-semialdehyde + CO2
-
 ?
2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate
-
 Rattus norvegicus 2-aminomuconate-6-semialdehyde + CO2
-
 ?

Synonyms

Synonyms Comment Organism
ACMSD
-
 Mus musculus
ACMSD
-
 Homo sapiens
ACMSD
-
 Rattus norvegicus
alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase
-
 Mus musculus
alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase
-
 Homo sapiens
alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase
-
 Rattus norvegicus