Literature summary for 4.1.1.45 extracted from

Ichiyama, A.; Nakamura, S.; Kawai, H.; Honjo, T.; Nishizuka, Y.; Hayaishi, O.; Senoh, S.
Studies on the metabolism of the benzene ring of tryptophan in mammalian tissues II. Enzymic formation of alpha-aminomuconic acid from 3-hydroxyanthranilic acid (1965), J. Biol. Chem., 240, 740-749.

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Inhibitors

Inhibitors	Comment	Organism	Structure
2-hydroxymuconate 6-semialdehyde	-	Felis catus
CuSO4	-	Felis catus
HgCl2	-	Felis catus
PCMB	inhibition is prevented by either reduced glutathione or caseine	Felis catus

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.001	-	2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate	-	Felis catus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate	Felis catus	enzyme is involved in the metabolism of the benzene ring	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Felis catus	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Felis catus

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Felis catus	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
additional information	-	-	Felis catus

Storage Stability

Storage Stability	Organism
-20°C, stable for several months	Felis catus

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate	-	Felis catus	2-aminomuconate semialdehyde + CO2	-	?
2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate	enzyme is involved in the metabolism of the benzene ring	Felis catus	?	-	?

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
6	9.5	-	Felis catus

pH Stability

pH Stability	pH Stability Maximum	Comment	Organism
6	9.5	stable	Felis catus

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Release 2023.1 (January 2023)