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Literature summary for 4.1.1.37 extracted from

  • Cunha, L.; Kuti, M.; Bishop, D.F.; Mezei, M.; Zeng, L.; Zhou, M.M.; Desnick, R.J.
    Human uroporphyrinogen III synthase: NMR-based mapping of the active site (2007), Proteins, 71, 855-873.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli strain Top10 Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
41070
-
mass spectrometry Homo sapiens
41070
-
calculated from amino acid sequence Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
IMAC column chromatography, Mono Q column chromatography, and Superdex 70 gel filtration Homo sapiens

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.75
-
crude enzyme, at 37°C Homo sapiens
7.6
-
purified enzyme, at 37°C Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
uroporphyrinogen I
-
Homo sapiens coproporphyrinogen I + 4 CO2
-
?

Synonyms

Synonyms Comment Organism
Uro-decarboxylase
-
Homo sapiens
uroporphyrinogen-decarboxylase
-
Homo sapiens

pH Range

pH Minimum pH Maximum Comment Organism
5 8 in 0.2 M KH2PO4, 0.1 mM dithiothreitol Homo sapiens