Inhibitors | Comment | Organism | Structure |
---|---|---|---|
5,5'-dithiobis(2-nitrobenzoate) | - |
Homo sapiens | |
Cu2+ | strong | Homo sapiens | |
Fe2+ | weak | Homo sapiens | |
Hg2+ | strong | Homo sapiens | |
iodoacetamide | - |
Homo sapiens | |
NEM | - |
Homo sapiens | |
p-hydroxymercuribenzoate | - |
Homo sapiens | |
Pt2+ | strong | Homo sapiens | |
Sn2+ | weak | Homo sapiens | |
Zn2+ | weak | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00005 | - |
5-COOH-porphyrinogen III | - |
Homo sapiens | |
0.00007 | - |
5-COOH-porphyrinogen I | - |
Homo sapiens | |
0.00035 | - |
7-COOH-porphyrinogen III | - |
Homo sapiens | |
0.0008 | - |
Uroporphyrinogen I | - |
Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
46000 | - |
1 * 46000, SDS-PAGE | Homo sapiens |
58000 | - |
gel filtration | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
erythrocyte | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.17 | - |
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5-COOH-porphyrinogen I | - |
Homo sapiens | Coproporphyrinogen I + CO2 | - |
? | |
5-COOH-porphyrinogen III | - |
Homo sapiens | Coproporphyrinogen III + CO2 | - |
? | |
7-COOH-porphyrinogen III | - |
Homo sapiens | Coproporphyrinogen III + CO2 | - |
? | |
uroporphyrinogen I | - |
Homo sapiens | coproporphyrinogen I + 4 CO2 | - |
? | |
Uroporphyrinogen III | - |
Homo sapiens | Coproporphyrinogen III + 4 CO2 | - |
? |
Subunits | Comment | Organism |
---|---|---|
monomer | 1 * 46000, SDS-PAGE | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
5.4 | - |
5-COOH-porphyrinogen I as substrate | Homo sapiens |
6.2 | - |
with uroporphyrinogen I as substrate | Homo sapiens |
6.8 | - |
with uroporphyrinogen III or 5-COOH-porphyrinogen III as substrate | Homo sapiens |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
5 | 6.6 | pH 5.0: about 80% of maximal activity, pH 6.6: about 40% of maximal activity, 5-COOH-porphyrinogen I | Homo sapiens |
5.8 | 7.8 | pH 5.8: about 60% of maximal activity, pH 7.8: about 55% of maximal activity, 5-COOH-porphyrinogen III | Homo sapiens |
5.8 | 7.4 | pH 5.8: about 65% of maximal activity, pH 7.4: about 45% of maximal activity, uroporphyrinogen I | Homo sapiens |
6 | 7.2 | pH 6.0: about 50% of maximal activity, pH 7.2: about 60% of maximal activity, uroporphyrinogen III | Homo sapiens |