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Literature summary for 4.1.1.36 extracted from
- Pantothenic acid and coenzyme A: phosphopantothenoylcysteine decarboxylase from rat liver [4'-phospho-N-(D-pantothenoyl)-L-cysteine carboxy-lyase, EC 4.1.1.36] (1970), Methods Enzymol., 18, 354-364.
No PubMed abstract available
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| cysteine | - |
Rattus norvegicus |  |
| GSH | activates | Rattus norvegicus | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| ATP | reversed by equimolar amount of semicarbazide | Rattus norvegicus | |
| additional information | no effect of ADP and AMP | Rattus norvegicus | |
| pantotheine 4-phosphate | competitive product inhibition | Rattus norvegicus | |
| pyridoxal | - |
Rattus norvegicus | |
| pyridoxal 5'-phosphate | - |
Rattus norvegicus | |
| UTP | - |
Rattus norvegicus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.133 | 0.15 | phosphopantothenoyl-L-Cys | - |
Rattus norvegicus | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| additional information | Mg2+ has no effect | Rattus norvegicus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.03 | - |
- |
Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| alpha-Carboxy-CoA | at low rate | Rattus norvegicus | ? | - |
? | |
| Dephospho-alpha-carboxy-CoA | at low rate | Rattus norvegicus | ? | - |
? | |
| additional information | pantothenylcysteine is decarboxylated | Rattus norvegicus | ? | - |
? | |
| N-((R)-4-Phosphopantothenoyl)-L-Cys | - |
Rattus norvegicus | Pantotheine 4-phosphate + CO2 | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | - |
- |
Rattus norvegicus |
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Release 2023.1 (January 2023)
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