Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 4.1.1.33 extracted from

  • Lefurgy, S.T.; Rodriguez, S.B.; Park, C.S.; Cahill, S.; Silverman, R.B.; Leyh, T.S.
    Probing ligand-binding pockets of the mevalonate pathway enzymes from Streptococcus pneumoniae (2010), J. Biol. Chem., 285, 20654-20663.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.1.1.33

Application

Application Comment Organism
pharmacology the enzyme is an antibiotic target, since inhibition prevents the production of isopentenyl diphosphate Streptococcus pneumoniae

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.001
-
 (3R)-3-cyclopropyl-3-hydroxy-5-[[hydroxy(phosphonooxy)phosphoryl]oxy]pentanoic acid
-
 Streptococcus pneumoniae
0.0012
-
 diphosphomevalonate
-
 Streptococcus pneumoniae
0.0015
-
 (3R)-3-ethyl-3-hydroxy-5-[[hydroxy(phosphonooxy)phosphoryl]oxy]pentanoic acid
-
 Streptococcus pneumoniae
0.0017
-
 (3R)-3-hydroxy-3-(2-[[hydroxy(phosphonooxy)phosphoryl]oxy]ethyl)pent-4-enoic acid
-
 Streptococcus pneumoniae
0.0028
-
 (3R)-3-hydroxy-3-(2-[[hydroxy(phosphonooxy)phosphoryl]oxy]ethyl)hex-5-enoic acid
-
 Streptococcus pneumoniae
0.0029
-
 (3R)-3-hydroxy-3-(2-[[hydroxy(phosphonooxy)phosphoryl]oxy]ethyl)pent-4-ynoic acid
-
 Streptococcus pneumoniae
0.0063
-
 (3R)-3-hydroxy-3-(2-[[hydroxy(phosphonooxy)phosphoryl]oxy]ethyl)hex-4-ynoic acid
-
 Streptococcus pneumoniae
0.016
-
 (3R)-3-hydroxy-3-(2-[[hydroxy(phosphonooxy)phosphoryl]oxy]ethyl)-4-methylpentanoic acid
-
 Streptococcus pneumoniae
0.029
-
 (3R)-3-hydroxy-3-(2-[[hydroxy(phosphonooxy)phosphoryl]oxy]ethyl)-5-methylhexanoic acid
-
 Streptococcus pneumoniae

Organism

Organism UniProt Comment Textmining
Streptococcus pneumoniae
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(3R)-3-cyclopropyl-3-hydroxy-5-[[hydroxy(phosphonooxy)phosphoryl]oxy]pentanoic acid + ATP
-
 Streptococcus pneumoniae ?
-
 ?
(3R)-3-ethyl-3-hydroxy-5-[[hydroxy(phosphonooxy)phosphoryl]oxy]pentanoic acid + ATP
-
 Streptococcus pneumoniae ?
-
 ?
(3R)-3-hydroxy-3-(2-[[hydroxy(phosphonooxy)phosphoryl]oxy]ethyl)-4-methylpent-4-enoic acid + ATP
-
 Streptococcus pneumoniae ?
-
 ?
(3R)-3-hydroxy-3-(2-[[hydroxy(phosphonooxy)phosphoryl]oxy]ethyl)-4-methylpentanoic acid + ATP
-
 Streptococcus pneumoniae ?
-
 ?
(3R)-3-hydroxy-3-(2-[[hydroxy(phosphonooxy)phosphoryl]oxy]ethyl)-5-methylhexanoic acid + ATP
-
 Streptococcus pneumoniae ?
-
 ?
(3R)-3-hydroxy-3-(2-[[hydroxy(phosphonooxy)phosphoryl]oxy]ethyl)heptanoic acid + ATP
-
 Streptococcus pneumoniae ?
-
 ?
(3R)-3-hydroxy-3-(2-[[hydroxy(phosphonooxy)phosphoryl]oxy]ethyl)hex-4-ynoic acid + ATP
-
 Streptococcus pneumoniae ?
-
 ?
(3R)-3-hydroxy-3-(2-[[hydroxy(phosphonooxy)phosphoryl]oxy]ethyl)hex-5-enoic acid + ATP
-
 Streptococcus pneumoniae ?
-
 ?
(3R)-3-hydroxy-3-(2-[[hydroxy(phosphonooxy)phosphoryl]oxy]ethyl)pent-4-enoic acid + ATP
-
 Streptococcus pneumoniae ?
-
 ?
(3R)-3-hydroxy-3-(2-[[hydroxy(phosphonooxy)phosphoryl]oxy]ethyl)pent-4-ynoic acid + ATP
-
 Streptococcus pneumoniae ?
-
 ?
diphosphomevalonate + ATP
-
 Streptococcus pneumoniae isopentenyl diphosphate + ADP
-
 ?

Synonyms

Synonyms Comment Organism
diphosphomevalonate decarboxylase
-
 Streptococcus pneumoniae
DPM-DC
-
 Streptococcus pneumoniae

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.018
-
 (3R)-3-hydroxy-3-(2-[[hydroxy(phosphonooxy)phosphoryl]oxy]ethyl)-4-methylpentanoic acid
-
 Streptococcus pneumoniae
0.024
-
 (3R)-3-hydroxy-3-(2-[[hydroxy(phosphonooxy)phosphoryl]oxy]ethyl)-5-methylhexanoic acid
-
 Streptococcus pneumoniae
0.21
-
 (3R)-3-hydroxy-3-(2-[[hydroxy(phosphonooxy)phosphoryl]oxy]ethyl)hex-4-ynoic acid
-
 Streptococcus pneumoniae
0.27
-
 (3R)-3-cyclopropyl-3-hydroxy-5-[[hydroxy(phosphonooxy)phosphoryl]oxy]pentanoic acid
-
 Streptococcus pneumoniae
0.39
-
 (3R)-3-hydroxy-3-(2-[[hydroxy(phosphonooxy)phosphoryl]oxy]ethyl)hex-5-enoic acid
-
 Streptococcus pneumoniae
1.3
-
 (3R)-3-ethyl-3-hydroxy-5-[[hydroxy(phosphonooxy)phosphoryl]oxy]pentanoic acid
-
 Streptococcus pneumoniae
1.3
-
 (3R)-3-hydroxy-3-(2-[[hydroxy(phosphonooxy)phosphoryl]oxy]ethyl)pent-4-ynoic acid
-
 Streptococcus pneumoniae
3.2
-
 (3R)-3-hydroxy-3-(2-[[hydroxy(phosphonooxy)phosphoryl]oxy]ethyl)pent-4-enoic acid
-
 Streptococcus pneumoniae
5.6
-
 diphosphomevalonate
-
 Streptococcus pneumoniae

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
0.54
-
 (3R)-3-hydroxy-3-(2-[[hydroxy(phosphonooxy)phosphoryl]oxy]ethyl)-4-methylpent-4-enoic acid
-
 Streptococcus pneumoniae
0.8
-
 (3R)-3-hydroxy-3-(2-[[hydroxy(phosphonooxy)phosphoryl]oxy]ethyl)-5-methylhexanoic acid
-
 Streptococcus pneumoniae
1
-
 (3R)-3-hydroxy-3-(2-[[hydroxy(phosphonooxy)phosphoryl]oxy]ethyl)-4-methylpentanoic acid
-
 Streptococcus pneumoniae
12
-
 (3R)-3-hydroxy-3-(2-[[hydroxy(phosphonooxy)phosphoryl]oxy]ethyl)heptanoic acid
-
 Streptococcus pneumoniae
33
-
 (3R)-3-hydroxy-3-(2-[[hydroxy(phosphonooxy)phosphoryl]oxy]ethyl)hex-4-ynoic acid
-
 Streptococcus pneumoniae
139
-
 (3R)-3-hydroxy-3-(2-[[hydroxy(phosphonooxy)phosphoryl]oxy]ethyl)hex-5-enoic acid
-
 Streptococcus pneumoniae
270
-
 (3R)-3-cyclopropyl-3-hydroxy-5-[[hydroxy(phosphonooxy)phosphoryl]oxy]pentanoic acid
-
 Streptococcus pneumoniae
448
-
 (3R)-3-hydroxy-3-(2-[[hydroxy(phosphonooxy)phosphoryl]oxy]ethyl)pent-4-ynoic acid
-
 Streptococcus pneumoniae
866
-
 (3R)-3-ethyl-3-hydroxy-5-[[hydroxy(phosphonooxy)phosphoryl]oxy]pentanoic acid
-
 Streptococcus pneumoniae
1882
-
 (3R)-3-hydroxy-3-(2-[[hydroxy(phosphonooxy)phosphoryl]oxy]ethyl)pent-4-enoic acid
-
 Streptococcus pneumoniae
4666
-
 diphosphomevalonate
-
 Streptococcus pneumoniae