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Literature summary for 4.1.1.31 extracted from
- Phosphoenolpyruvate carboxylase from C4 leaves is selectively targeted for inhibition by anionic phospholipids (2010), Plant Physiol., 152, 634-638.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| lyso-phosphatidic acid | addition of 0.05 mM phosphatidic acid decreases PEPC activity to approximately 45% of the control activity | Sorghum bicolor |  |
| lyso-phosphatidic acid | addition of 0.05 mM phosphatidic acid decreases PEPC activity to approximately 45% of the control activity | Zea mays | |
| additional information | not inhibited by phosphatidic acid, phosphatidylinositol, phosphatidylinositol 4-phosphate, lyso-phosphatidic acid, phosphatidylserine, phosphatidylcholine, and phosphatidylethanolamine | Arabidopsis thaliana | |
| additional information | phosphatidylcholine and phosphatidylethanolamine have no effect on enzyme activity | Sorghum bicolor | |
| additional information | phosphatidylcholine and phosphatidylethanolamine have no effect on enzyme activity | Zea mays | |
| phosphatidic acid | addition of 0.05 mM phosphatidic acid decreases PEPC activity to approximately 40% of the control activity. Inclusion of D-glucose 6-phosphate or L-malate do not change the effect of phosphatidic acid on PEPC, preincubation of the enzyme with 5 mM phosphoenolpyruvate prior to the addition of phosphatidic acid did not prevent inactivation either. The incubation of phosphatidic acid-inactivated PEPC with protein kinase A does not restore PEPC activity | Sorghum bicolor | |
| phosphatidic acid | addition of 0.05 mM phosphatidic acid decreases PEPC activity to approximately 40% of the control activity. Inclusion of D-glucose 6-phosphate or L-malate do not change the effect of phosphatidic acid on PEPC, preincubation of the enzyme with 5 mM phosphoenolpyruvate prior to the addition of phosphatidic acid did not prevent inactivation either. The incubation of phosphatidic acid-inactivated PEPC with protein kinase A does not restore PEPC activity | Zea mays | |
| phosphatidylinositol | addition of 0.05 mM phosphatidic acid decreases PEPC activity to approximately 40% of the control activity | Sorghum bicolor | |
| phosphatidylinositol | addition of 0.05 mM phosphatidic acid decreases PEPC activity to approximately 40% of the control activity | Zea mays | |
| phosphatidylinositol 4-phosphate | addition of 0.05 mM phosphatidic acid decreases PEPC activity to approximately 50% of the control activity | Sorghum bicolor | |
| phosphatidylinositol 4-phosphate | addition of 0.05 mM phosphatidic acid decreases PEPC activity to approximately 50% of the control activity | Zea mays | |
| phosphatidylserine | addition of 0.05 mM phosphatidic acid decreases PEPC activity to approximately 80% of the control activity | Sorghum bicolor | |
| phosphatidylserine | addition of 0.05 mM phosphatidic acid decreases PEPC activity to approximately 80% of the control activity | Zea mays | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | the enzyme partially localizes to membranes | Zea mays | 16020 | - |
| membrane | the enzyme partially localizes to membranes | Arabidopsis thaliana | 16020 | - |
| membrane | the enzyme partially localizes to membranes | Sorghum bicolor | 16020 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Arabidopsis thaliana | - |
- |
- |
| Sorghum bicolor | - |
- |
- |
| Zea mays | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| leaf | - |
Zea mays | - |
| leaf | - |
Arabidopsis thaliana | - |
| leaf | - |
Sorghum bicolor | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| phosphoenolpyruvate + CO2 | - |
Zea mays | phosphate + oxaloacetate | - |
ir | |
| phosphoenolpyruvate + CO2 | - |
Arabidopsis thaliana | phosphate + oxaloacetate | - |
ir | |
| phosphoenolpyruvate + CO2 | - |
Sorghum bicolor | phosphate + oxaloacetate | - |
ir | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| C4 PEPC | - |
Zea mays |
| C4 PEPC | - |
Arabidopsis thaliana |
| C4 PEPC | - |
Sorghum bicolor |
| PEPC | - |
Zea mays |
| PEPC | - |
Arabidopsis thaliana |
| PEPC | - |
Sorghum bicolor |
| phosphoenolpyruvate carboxykinase | - |
Arabidopsis thaliana |
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Release 2023.1 (January 2023)
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