Literature summary for 4.1.1.28 extracted from

Shih, D.F.; Hsiao, C.D.; Min, M.Y.; Lai, W.S.; Yang, C.W.; Lee, W.T.; Lee, S.J.
Aromatic L-amino acid decarboxylase (AADC) is crucial for brain development and motor functions (2013), PLoS ONE, 8, e71741.

Search for more literature for 4.1.1.28

Application

Application	Comment	Organism
analysis	loss of dopa decarboxylase appears to result in similar phenotypes as those of aromatic L-amino acid decarboxylase deficiency, thus zebrafish could be a good model for investigating pathogenetic mechanisms of aromatic L-amino acid decarboxylase deficiency in children	Danio rerio

Organism

Organism	UniProt	Comment	Textmining
Danio rerio	Q7SZR0	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
diencephalon	diencephalic catecholaminergic cluster and locus caeruleus of 36-h post-fertilization zebrafish embryos	Danio rerio	-
embryo	epiphysis, locus caeruleus, diencephalic catecholaminergic clusters, and raphe nuclei of 36-h post-fertilization zebrafish embryos	Danio rerio	-
epiphysis	of 36-h post-fertilization zebrafish embryos	Danio rerio	-
raphe nucleus	of 36-h post-fertilization zebrafish embryos	Danio rerio	-

Synonyms

Synonyms	Comment	Organism
DDC	-	Danio rerio

General Information

General Information	Comment	Organism
physiological function	inhibition of dopa dearboxylase by inhibitor NSD-1015 or anti-sense morpholino oligonucleotides reduces brain volume and body length. Oligonucleotide-treated emryos display brain cell apoptosis and loss of dipencephalic catecholaminergic cluster neurons as well as seizure-like activity in a dose-dependent manner. Treated embroys have less sensitive touch response and impaired swimming activity that can be rescued by injection of plasmids carrying the dopa decarboxylase gene. In addition, eye movement is significantly impaired in treated embryos	Danio rerio

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Release 2023.1 (January 2023)