Literature summary for 4.1.1.28 extracted from

Montioli, R.; Cellini, B.; Dindo, M.; Oppici, E.; Voltattorni, C.
Interaction of human Dopa decarboxylase with L-dopa: Spectroscopic and kinetic studies as a function of pH (2013), BioMed Res. Int., 2013, 161456.

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3,4-Dihydroxyphenylalanine	during the reaction with L-Dopa, monitored by stopped-flow spectrophotometry, a 420 nm band attributed to the 4'-N-protonated external aldimine first appears, and its decrease parallels the emergence of a 390 nm peak, assigned to the 4'-N-unprotonated external aldimine. The pH profile of the spectral change at 390 nm displays a pK of 6.4, which may represent the ESH(+) -> ES catalytic step	Homo sapiens	Dopamine + CO2	-	?

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Release 2023.1 (January 2023)