Literature summary for 4.1.1.28 extracted from

Gil, S.; Park, C.; Lee, J.; Koh, H.
The roles of striatal serotonin and L-amino-acid decarboxylase on L-DOPA-induced dyskinesia in a hemiparkinsonian rat model (2010), Cell. Mol. Neurobiol., 30, 817-825.

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Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
5-Hydroxytryptophan	-	Rattus norvegicus	Serotonin + CO2	-	?
L-Dopa	-	Rattus norvegicus	dopamine + CO2	-	?

Synonyms

Synonyms	Comment	Organism
AADC	-	Rattus norvegicus
L-amino-acid decarboxylase	-	Rattus norvegicus

Cofactor

Cofactor	Comment	Organism	Structure
pyridoxal 5'-phosphate	-	Rattus norvegicus

Expression

Organism	Comment	Expression
Rattus norvegicus	AADC expression in the L-DOPA naive 6-hydroxydopamine-lesioned rats does decrease significantly as compared with intact striata	down

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Release 2023.1 (January 2023)