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Literature summary for 4.1.1.28 extracted from

  • Eberling, J.L.; Jagust, W.J.; Christine, C.W.; Starr, P.; Larson, P.; Bankiewicz, K.S.; Aminoff, M.J.
    Results from a phase I safety trial of hAADC gene therapy for Parkinson disease (2008), Neurology, 70, 1980-1983.
    View publication on PubMed

Application

Application Comment Organism
drug development Parkinson disease, gene therapy, initiation of a phase I safety trial Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
in a primate model of Parkinson disease, intrastriatal infusion of an adeno-associated viral vector containing the AADC gene results in robust gene expression Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-3,4-Dihydroxyphenylalanine Homo sapiens L-dopa Dopamine + CO2
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
neuron striatal neurons Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
after gene transfer in nondegenerating striatal neurons in patients, transgene expression of AADC can be monitored in the putamen Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-3,4-Dihydroxyphenylalanine L-dopa Homo sapiens Dopamine + CO2
-
?

Synonyms

Synonyms Comment Organism
Aromatic L-amino acid decarboxylase
-
Homo sapiens