Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | A conserved AP-1 (JNK activated transcription factor complex) binding upstream of the DDC transcription start site is necessary to induce DDC transcription | Drosophila melanogaster | |
additional information | aseptic wounding of larvae or adults does not lead to DDC transcriptional induction, unlike in embryos where DDC activity at the edge of the wound contributes to the formation of a melanin clot | Drosophila melanogaster | |
additional information | Transcription of the dopa decarboxylase gene is induced in response to gram-negative and gram-positive septic injury, but not aseptic wounding. Ddc transcripts are detectible within 2 h and remain high for several hours following infection with either gram-negative (Escherichia coli) or gram-positive (Staphylococcus aureus) bacteria. Ddc transcription depends on a previously uncharacterized member of the p38 mitogen-activated protein kinase family, p38c | Drosophila melanogaster |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-Dopa | Drosophila melanogaster | - |
dopamine + CO2 | dopamine has a neural role and is metabolized to produce melanin and sclerotin in epidermal tissues | ? | |
additional information | Drosophila melanogaster | DDC activity is required in the epidermis for the synthesis of dopamine that is metabolized to produce reactive quinones that exert killing effects on invading bacteria | ? | - |
? | |
additional information | Drosophila melanogaster | DDC plays a role in the Drosophila innate immune response in larvae and adults | ? | - |
? | |
additional information | Drosophila melanogaster | dopa decarboxylase plays an essential role in wound healing in the Drosophila embryo | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Drosophila melanogaster | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
epidermis | transcription of DDC is induced when larvae or adults are infected, transcription is induced throughout the epidermis and not specifically at the site of infection | Drosophila melanogaster | - |
head | DDC transcription is induced strongly in the flies that are septically injured with Eschericia coli or Staphylococcos aureus | Drosophila melanogaster | - |
thorax | DDC transcription is induced strongly in the flies that are septically injured with Eschericia coli or Staphylococcos aureus | Drosophila melanogaster | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-Dopa | - |
Drosophila melanogaster | dopamine + CO2 | dopamine has a neural role and is metabolized to produce melanin and sclerotin in epidermal tissues | ? | |
additional information | DDC activity is required in the epidermis for the synthesis of dopamine that is metabolized to produce reactive quinones that exert killing effects on invading bacteria | Drosophila melanogaster | ? | - |
? | |
additional information | DDC plays a role in the Drosophila innate immune response in larvae and adults | Drosophila melanogaster | ? | - |
? | |
additional information | dopa decarboxylase plays an essential role in wound healing in the Drosophila embryo | Drosophila melanogaster | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DDC | - |
Drosophila melanogaster |
DOPA decarboxylase | - |
Drosophila melanogaster |